Application | Comment | Organism |
---|---|---|
medicine | GzmM initiates caspase-dependent apoptosis, induces DNA fragmentation, but not DNA nicking, Pro-Ject protein transfection reagent can efficiently transport GZmM into target cells | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Pichia pastoris | Homo sapiens |
expressed in Pichia pastoris strain X33 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S182A | inactive | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by Ni-affinity chromatography | Homo sapiens |
nickel affinity column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inhibitor of caspase-activated DNase + H2O | - |
Homo sapiens | ? | - |
? | |
inhibitor of caspase-activated DNase + H2O | direct degradation to release the nuclease activity of caspase-activated DNase for damaging DNA | Homo sapiens | ? | - |
? | |
poly(ADP-ribose) polymerase + H2O | - |
Homo sapiens | ? | - |
? | |
poly(ADP-ribose) polymerase + H2O | cleavage to prevent cellular DNA repair and force apoptosis | Homo sapiens | ? | - |
? | |
succinyl-Ala-Ala-Pro-Leu-4-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GZmM | - |
Homo sapiens |