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Literature summary for 3.4.21.B2 extracted from
- Granzyme M mediates a novel form of perforin-dependent cell death (2004), J. Biol. Chem., 279, 22236-22242.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in the presence of perforin, the protease activity of GrM rapidly and effectively induces target cell death, but does not feature obvious DNA fragmentation, occurs independently of caspases, caspase activation, and perturbation of mitochondria | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not inhibited by overexpression of Bcl-2 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GrM | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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