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Literature summary for 3.4.21.B2 extracted from

  • Smyth, M.J.; O'Connor, M.D.; Trapani, J.A.; Kershaw, M.H.; Brinkworth, R.I.
    A novel substrate-binding pocket interaction restricts the specificity of the human NK cell-specific serine protease, Met-ase-1 (1996), J. Immunol., 156, 4174-4181.
    View publication on PubMed
Search for more literature for 3.4.21.B2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
K179M reduced activity for substrate containing methionine at P1, acquired chymase activity for phenylalanine at P1 Homo sapiens
S201G reduced activity for substrate containing methionine at P1, acquired chymase activity for phenylalanine at P1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens participates in target cell death inflicted by cytotoxic lymphocytes ?
-
 ?
Protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cleaves the carboxyl side of long narrow hydrophobic amino acids, such as methionine, but not large, bulky hydrophobic amino acids such as phenylalanine Homo sapiens ?
-
 ?
additional information participates in target cell death inflicted by cytotoxic lymphocytes Homo sapiens ?
-
 ?
N-tert-butoxycarbonyl-Ala-Ala-Met-thiobenzyl ester + H2O cleaves thiobenzylester substrates specifically after methionine, norleucine or leucine residues in the primary substrate site P1 Homo sapiens N-tert-butoxycarbonyl-Ala-Ala-Met + phenylmethanethiol
-
 ?
Protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Met-ase-1
-
 Homo sapiens
S01.139 Merops ID Homo sapiens