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Literature summary for 3.4.21.B12 extracted from

  • Papagerakis, P.; Pannone, G.; Zheng, L.I.; Athanassiou-Papaefthymiou, M.; Yamakoshi, Y.; McGuff, H.S.; Shkeir, O.; Ghirtis, K.; Papagerakis, S.
    Clinical significance of kallikrein-related peptidase-4 in oral cancer (2015), Anticancer Res., 35, 1861-1866 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B12

Application

Application Comment Organism
medicine KLK4 can serve as a potential therapeutic target in patients with oral cancer. Inhibition of KLK4 expression results in diminished invasive potential in OSCC cell lines Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition of KLK4 expression results in diminished invasive potential in OSCC cell lines Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y5K2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CAL-27 cell
-
 Homo sapiens
-
oral squamous cell carcinoma cell KLK4 is differentially expressed in oral carcinomas. OSCC cell lines with high invasive and metastatic potential have the highest levels of KLK4 expression Homo sapiens
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Synonyms

Synonyms Comment Organism
kallikrein-related peptidase-4
-
 Homo sapiens
KLK4
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme serves vital functions in dental enamel formation. KLK4 is involved in degradation of extracellular matrix proteins and it is thought that this proteolytic activity can also promote tumor invasion and metastasis. KLK4 expression is stronger in primary tumors that later either recurred or developed metastases, suggesting that its preferential expression in OSCC might contribute to individual tumor biology Homo sapiens