KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.049 | - |
VPR-7-amido-4-methylcoumarin | pH 8.0, 37°C | Homo sapiens | |
0.052 | - |
VLK-7-amido-4-methylcoumarin | pH 8.0, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
x * 30000, glycosylated form, x * 25000, deglycosylated form, SDS-PAGE | Homo sapiens |
30000 | - |
x * 30000, glycosylated form, x * 25000, deglycosylated form, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme is involved in tissue remodeling and cancer metastasis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
expressed in Pichia pastoris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen I + H2O | limited degradation | Homo sapiens | ? | - |
? | |
Collagen IV + H2O | limited degradation | Homo sapiens | ? | - |
? | |
EKK-7-amido-4-methylcoumarin + H2O | 9% of the activity with VPR-7-amido-4-methylcoumarin | Homo sapiens | EKK + 7-amino-4-methylcoumarin | - |
? | |
fibrinogen alpha-chain + H2O | - |
Homo sapiens | ? | - |
? | |
GPR-7-amido-4-methylcoumarin + H2O | 20% of the activity with VPR-7-amido-4-methylcoumarin | Homo sapiens | GPR + 7-amino-4-methylcoumarin | - |
? | |
additional information | enzyme is involved in tissue remodeling and cancer metastasis | Homo sapiens | ? | - |
? | |
additional information | enzyme cleaves more efficiently after Arg compared to Lys at the P1 position and exhibits modest specificity for amino acids at P2 and P3 positions | Homo sapiens | ? | - |
? | |
QAR-7-amido-4-methylcoumarin + H2O | 38% of the activity with VPR-7-amido-4-methylcoumarin | Homo sapiens | QAR + 7-amino-4-methylcoumarin | - |
? | |
VLK-7-amido-4-methylcoumarin + H2O | 60% of the activity with VPR-7-amido-4-methylcoumarin | Homo sapiens | VLK + 7-amino-4-methylcoumarin | - |
? | |
VPR-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | VPR + 7-amino-4-methylcoumarin | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 30000, glycosylated form, x * 25000, deglycosylated form, SDS-PAGE | Homo sapiens |
More | enzyme forms complexes with alpha1-antitrypsin, alpha2-antiplasmin and alpha2-macroglobulin | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0078 | - |
VLK-7-amido-4-methylcoumarin | pH 8.0, 37°C | Homo sapiens | |
0.033 | - |
VPR-7-amido-4-methylcoumarin | pH 8.0, 37°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Homo sapiens |