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Literature summary for 3.4.21.B10 extracted from

  • Kishibe, M.; Baida, G.; Bhalla, P.; Lavker, R.M.; Schlosser, B.; Iinuma, S.; Yoshida, S.; Dudley, J.T.; Budunova, I.
    Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids (2016), Oncotarget, 7, 69479-69488 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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Synonyms

Synonyms Comment Organism
kallikrein 6
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Mus musculus

General Information

General Information Comment Organism
malfunction KLK6 knockout mice have thinner epidermis and decreased keratinocyte proliferation. The keratinocytes in wild type and KLK6 knockout epidermis are equally sensitive to acute anti-proliferative effect of fluocinolone acetonide. The development of proliferative resistance during chronic treatment is reduced in knockout epidermis Mus musculus
metabolism mechanism of epidermal regeneration after glucocorticoid-induced atrophy via KLK6 activation Mus musculus