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Literature summary for 3.4.21.B10 extracted from
- Kallikrein-related peptidase 6 orchestrates astrocyte form and function through proteinase activated receptor-dependent mechanisms (2018), Biol. Chem., 399, 1041-1052 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| central nervous system | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| kallikrein-related peptidase 6 | - |
Mus musculus |
| KLK6 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme can influence astrocyte plasticity through receptor-dependent mechanisms. Recombinant Klk6 evokes increases in intracellular Ca2+ in primary astrocyte monolayer cultures through activation of proteinase activated receptor 1 (PAR1). Klk6 promotes a condensation of astrocyte cortical actin leading to an elongated stellate shape and multicellular aggregation in a manner that is dependent on the presence of either PAR1 or PAR2. Klk6-evoked changes in astrocyte shape are accompanied by translocation of beta-catenin from the plasma membrane to the cytoplasm | Mus musculus |
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Release 2023.1 (January 2023)
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