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Literature summary for 3.4.21.B10 extracted from

  • Silva, R.N.; Oliveira, L.C.G.; Parise, C.B.; Oliveira, J.R.; Severino, B.; Corvino, A.; di Vaio, P.; Temussi, P.A.; Caliendo, G.; Santagada, V.; Juliano, L.; Juliano, M.A.
    Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease? (2017), Biochim. Biophys. Acta, 1865, 558-564 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Abz-Phe-Arg-Lys-Gln-EDDnp
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00036
-
Abz-Leu-Leu-Ala-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Lys-Lys-Met-Asp-Glu-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.0012
-
Abz-Lys-Leu-Arg-Ser-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.0017
-
Abz-Arg-Thr-Ser-Arg-Arg-Lys-Arg-Tyr-Ala-Glu-His-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.0018
-
Abz-Asp-Met-Ser-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Arg-Ser-Leu-Lys-Arg-Ser-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.0026
-
Abz-Lys-Leu-Arg-Ser-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.004
-
benzoyl-Ala-Arg-Arg-7-amido-4-carbamoylmethylcoumarin pH 7.5, 37°C Homo sapiens
0.0046
-
Abz-Glu-Glu-Val-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Arg-Gly-Leu-Lys-Arg-Ser-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.0074
-
Abz-Thr-His-Arg-Ser-Lys-Arg-Ser-Ser-Ser-His-Pro-Ile-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.014
-
Abz-Ser-Met-Arg-Val-Arg-Arg-His-Ser-Asp-Pro-Ala-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.017
-
Abz-Lys-Leu-Arg-Arg-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.021
-
Abz-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-Gly-Phe-Leu-Lys-Arg-Phe-Ala-Glu-Ala-Leu-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.023
-
Abz-Phe-Arg-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.023
-
benzoyl-Ala-Lys-Arg-7-amido-4-carbamoylmethylcoumarin pH 7.5, 37°C Homo sapiens
0.025
-
Abz-Lys-Lys-Arg-Ser-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.026
-
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin pH 7.5, 37°C Homo sapiens
0.027
-
Abz-Lys-Arg-Arg-Ser-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.043
-
Abz-Phe-Arg-Arg-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.047
-
benzoyl-Ala-Phe-Arg-7-amido-4-carbamoylmethylcoumarin pH 7.5, 37°C Homo sapiens
0.053
-
Abz-Ala-Arg-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.055
-
Lys-Ala-Arg-Arg-7-amido-4-carbamoylmethylcoumarin pH 7.5, 37°C Homo sapiens
0.073
-
Abz-Ala-Arg-Arg-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.076
-
Abz-Ala-Lys-Arg-Gln-EDDnp pH 7.5, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92876
-
-

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system highly expressed in the central nervous system and with elevated level in demyelinating disease Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-Ala-Arg-Arg-Gln-EDDnp + H2O
-
Homo sapiens Abz-Ala-Arg + Args-Gln-EDDnp
-
?
Abz-Ala-Arg-Lys-Gln-EDDnp + H2O
-
Homo sapiens Abz-Ala-Arg + Lys-Gln-EDDnp
-
?
Abz-Ala-Lys-Arg-Gln-EDDnp + H2O
-
Homo sapiens Abz-Ala-Lys-Arg + Gln-EDDnp
-
?
Abz-Ala-Pro-Ala-Asn-Arg-Ser-Arg-Arg-Gly-Val-Ser-Glu-Thr-Gln-EDDnp + H2O
-
Homo sapiens Abz-Ala-Pro-Ala-Asn-Arg-Ser-Arg + Arg-Gly-Val-Ser-Glu-Thr-Gln-EDDnp
-
?
Abz-Arg-Thr-Ser-Arg-Arg-Lys-Arg-Tyr-Ala-Glu-His-Lys-Gln-EDDnp + H2O
-
Homo sapiens Abz-Arg-Thr-Ser-Arg-Arg-Lys-Arg + Tyr-Ala-Glu-His-Lys-Gln-EDDnp
-
?
Abz-Asp-Met-Ser-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Arg-Ser-Leu-Lys-Arg-Ser-Gln-EDDnp + H2O cleavage sites: Abz-Asp-Met-Ser-Lys-Arg-/-Tyr-Gly-Gly-Phe-Met-Arg-/-Ser-Leu-Lys-Arg-Ser-Gln-EDDnp Homo sapiens ?
-
?
Abz-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-Gly-Phe-Leu-Lys-Arg-Phe-Ala-Glu-Ala-Leu-Gln-EDDnp + H2O cleavage sites: Abz-Asp-Tyr-Gln-Lys-Arg-/-Tyr-Gly-Gly-Phe-Leu-Lys-Arg-/-Phe-Ala-Glu-Ala-Leu-Gln-EDDnp Homo sapiens ?
-
?
Abz-Glu-Glu-Val-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Arg-Gly-Leu-Lys-Arg-Ser-Gln-EDDnp + H2O cleavage sites: Abz-Glu-Glu-Val-Lys-Arg-/-Tyr-Gly-Gly-Phe-Met-Arg-/-Gly-Leu-Lys-Arg-Ser-Gln-EDDnp Homo sapiens ?
-
?
Abz-Leu-Leu-Ala-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Lys-Lys-Met-Asp-Glu-Gln-EDDnp + H2O cleavage sites: Abz-Leu-Leu-Ala-Lys-Arg-/-Tyr-Gly-Gly-Phe-Met-Lys-Arg-/-Tyr-Gly-Gly-Phe-Met-Lys-/-Lys-Met-Asp-Glu-Gln-EDDnp Homo sapiens ?
-
?
Abz-Lys-Arg-Arg-Ser-Ser-Lys-Gln-EDDnp + H2O
-
Homo sapiens Abz-Lys-Arg-Arg + Ser-Ser-Lys-Gln-EDDnp
-
?
Abz-Lys-Leu-Arg-Arg-Ser-Lys-Gln-EDDnp + H2O
-
Homo sapiens Abz-Lys-Leu-Arg + Arg-Ser-Lys-Gln-EDDnp + Abz-Lys-Leu-Arg-Arg + Ser-Lys-Gln-EDDnp
-
?
Abz-Lys-Leu-Arg-Ser-Ser-Lys-Gln-EDDnp + H2O
-
Homo sapiens Abz-Lys-Leu-Arg + Ser-Ser-Lys-Gln-EDDnp
-
?
Abz-Lys-Lys-Arg-Ser-Ser-Lys-Gln-EDDnp + H2O
-
Homo sapiens Abz-Lys-Lys-Arg + Ser-Ser-Lys-Gln-EDDnp
-
?
Abz-Phe-Arg-Arg-Gln-EDDnp + H2O
-
Homo sapiens Abz-Phe-Arg + Arg-Gln-EDDnp
-
?
Abz-Phe-Arg-Lys-Gln-EDDnp + H2O
-
Homo sapiens Abz-Phe-Arg + Lys-Gln-EDDnp
-
?
Abz-Ser-Met-Arg-Val-Arg-Arg-His-Ser-Asp-Pro-Ala-Gln-EDDnp + H2O
-
Homo sapiens Abz-Ser-Met-Arg-Val-Arg + Arg-His-Ser-Asp-Pro-Ala-Gln-EDDnp
-
?
Abz-Thr-His-Arg-Ser-Lys-Arg-Ser-Ser-Ser-His-Pro-Ile-Gln-EDDnp + H2O
-
Homo sapiens Abz-Thr-His-Arg-Ser-Lys-Arg + Ser-Ser-Ser-His-Pro-Ile-Gln-EDDnp
-
?
benzoyl-Ala-Arg-Arg-7-amido-4-carbamoylmethylcoumarin + H2O
-
Homo sapiens benzoyl-Ala-Arg + Arg-7-amido-4-carbamoylmethylcoumarin
-
?
benzoyl-Ala-Lys-Arg-7-amido-4-carbamoylmethylcoumarin + H2O
-
Homo sapiens benzoyl-Ala-Lys + Arg-7-amido-4-carbamoylmethylcoumarin
-
?
benzoyl-Ala-Phe-Arg-7-amido-4-carbamoylmethylcoumarin + H2O
-
Homo sapiens benzoyl-Ala-Phe + Arg-7-amido-4-carbamoylmethylcoumarin
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens benzoyl-Arg + Arg-7-amido-4-methylcoumarin
-
?
human ionotropic glutamate receptor subunit + H2O
-
Homo sapiens ?
-
?
human MMP-14 + H2O
-
Homo sapiens ?
-
?
Lys-Ala-Arg-Arg-7-amido-4-carbamoylmethylcoumarin + H2O
-
Homo sapiens Lys-Ala-Arg + Arg-7-amido-4-carbamoylmethylcoumarin
-
?
myelin basic protein + H2O
-
Homo sapiens ?
-
?
nerve growth factor + H2O
-
Homo sapiens ?
-
?
neurotrophin-3 + H2O
-
Homo sapiens ?
-
?
neurotrophin-4 + H2O
-
Homo sapiens ?
-
?
Proenkephalin + H2O
-
Homo sapiens Enkephalin + ?
-
?
protein activator receptor + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
kallikrein-related peptidase 6
-
Homo sapiens
KLK6
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.04
-
Abz-Ala-Arg-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.06
-
Abz-Asp-Met-Ser-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Arg-Ser-Leu-Lys-Arg-Ser-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.07
-
Abz-Arg-Thr-Ser-Arg-Arg-Lys-Arg-Tyr-Ala-Glu-His-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.08
-
Abz-Leu-Leu-Ala-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Lys-Lys-Met-Asp-Glu-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.08
-
Abz-Glu-Glu-Val-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Arg-Gly-Leu-Lys-Arg-Ser-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.09
-
Abz-Phe-Arg-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.1
-
Abz-Ser-Met-Arg-Val-Arg-Arg-His-Ser-Asp-Pro-Ala-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.18
-
Abz-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-Gly-Phe-Leu-Lys-Arg-Phe-Ala-Glu-Ala-Leu-Gln-EDDnp pH 7.5, 37°C Homo sapiens
0.2
-
Abz-Thr-His-Arg-Ser-Lys-Arg-Ser-Ser-Ser-His-Pro-Ile-Gln-EDDnp pH 7.5, 37°C Homo sapiens
1.5
-
Abz-Lys-Leu-Arg-Ser-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
1.95
-
Abz-Ala-Lys-Arg-Gln-EDDnp pH 7.5, 37°C Homo sapiens
2
-
Abz-Ala-Arg-Arg-Gln-EDDnp pH 7.5, 37°C Homo sapiens
2.4
-
Abz-Lys-Leu-Arg-Ser-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
2.5
-
benzoyl-Ala-Lys-Arg-7-amido-4-carbamoylmethylcoumarin pH 7.5, 37°C Homo sapiens
3
-
Abz-Phe-Arg-Arg-Gln-EDDnp pH 7.5, 37°C Homo sapiens
4.6
-
Abz-Lys-Arg-Arg-Ser-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
6.5
-
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin pH 7.5, 37°C Homo sapiens
8
-
benzoyl-Ala-Arg-Arg-7-amido-4-carbamoylmethylcoumarin pH 7.5, 37°C Homo sapiens
9
-
Abz-Lys-Leu-Arg-Arg-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
9.7
-
Lys-Ala-Arg-Arg-7-amido-4-carbamoylmethylcoumarin pH 7.5, 37°C Homo sapiens
10
-
benzoyl-Ala-Phe-Arg-7-amido-4-carbamoylmethylcoumarin pH 7.5, 37°C Homo sapiens
18
-
Abz-Lys-Lys-Arg-Ser-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.031
-
Abz-Phe-Arg-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.72
-
Abz-Ala-Arg-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
3.8
-
Abz-Phe-Arg-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
7
-
Abz-Ser-Met-Arg-Val-Arg-Arg-His-Ser-Asp-Pro-Ala-Gln-EDDnp pH 7.5, 37°C Homo sapiens
8.6
-
Abz-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-Gly-Phe-Leu-Lys-Arg-Phe-Ala-Glu-Ala-Leu-Gln-EDDnp pH 7.5, 37°C Homo sapiens
16
-
Abz-Glu-Glu-Val-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Arg-Gly-Leu-Lys-Arg-Ser-Gln-EDDnp pH 7.5, 37°C Homo sapiens
26
-
Abz-Ala-Lys-Arg-Gln-EDDnp pH 7.5, 37°C Homo sapiens
27
-
Abz-Ala-Arg-Arg-Gln-EDDnp pH 7.5, 37°C Homo sapiens
27
-
Abz-Thr-His-Arg-Ser-Lys-Arg-Ser-Ser-Ser-His-Pro-Ile-Gln-EDDnp pH 7.5, 37°C Homo sapiens
33
-
Abz-Asp-Met-Ser-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Arg-Ser-Leu-Lys-Arg-Ser-Gln-EDDnp pH 7.5, 37°C Homo sapiens
41
-
Abz-Arg-Thr-Ser-Arg-Arg-Lys-Arg-Tyr-Ala-Glu-His-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
70
-
Abz-Phe-Arg-Arg-Gln-EDDnp pH 7.5, 37°C Homo sapiens
107
-
benzoyl-Ala-Lys-Arg-7-amido-4-carbamoylmethylcoumarin pH 7.5, 37°C Homo sapiens
170
-
Abz-Lys-Arg-Arg-Ser-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
190
-
Lys-Ala-Arg-Arg-7-amido-4-carbamoylmethylcoumarin pH 7.5, 37°C Homo sapiens
210
-
benzoyl-Ala-Phe-Arg-7-amido-4-carbamoylmethylcoumarin pH 7.5, 37°C Homo sapiens
228
-
Abz-Leu-Leu-Ala-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Lys-Lys-Met-Asp-Glu-Gln-EDDnp pH 7.5, 37°C Homo sapiens
250
-
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin pH 7.5, 37°C Homo sapiens
529
-
Abz-Lys-Leu-Arg-Arg-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
570
-
Abz-Lys-Leu-Arg-Ser-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
720
-
Abz-Lys-Lys-Arg-Ser-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
1983
-
Abz-Lys-Leu-Arg-Ser-Ser-Lys-Gln-EDDnp pH 7.5, 37°C Homo sapiens
2000
-
benzoyl-Ala-Arg-Arg-7-amido-4-carbamoylmethylcoumarin pH 7.5, 37°C Homo sapiens