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Literature summary for 3.4.21.B10 extracted from

  • Scarisbrick, I.A.; Yoon, H.; Panos, M.; Larson, N.; Blaber, S.I.; Blaber, M.; Rodriguez, M.
    Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis (2012), Brain Pathol., 22, 709-722.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B10

Cloned(Commentary)

Cloned (Comment) Organism
gene Klk6, quantitative enzyme expression analysis Mus musculus
gene Klk6, quantitative enzyme expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information Klk6-neutralizing antibodies diminish spinal cord inflammation and demyelination to early chronic phases of disease Homo sapiens
additional information Klk6-neutralizing antibodies diminish spinal cord inflammation and demyelination to early chronic phases of disease Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92876
-
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Mus musculus
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 infected with Theiler's murine encephalomyelitis virus, gene Klk6
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Mus musculus SJL/J
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 infected with Theiler's murine encephalomyelitis virus, gene Klk6
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Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
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brain
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 Homo sapiens
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monocyte
-
 Mus musculus
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monocyte
-
 Homo sapiens
-
additional information in SJL mice infected with Theiler's murine encephalomyelitis virus, enzyme expression persisted primarily in the spinal cord reaching a peak of fivefold over controls at mid-chronic stages, expression of Klk6 RNA is differentially regulated in the brain and spinal cord across the acute, subacute and more chronic phases, overview Mus musculus
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spinal cord
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 Mus musculus
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spinal cord
-
 Homo sapiens
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splenocyte
-
 Mus musculus
-
splenocyte
-
 Homo sapiens
-
THP-1 cell
-
 Mus musculus
-
THP-1 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
kallikrein 6
-
 Mus musculus
kallikrein 6
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 Homo sapiens
KLK6
-
 Mus musculus
KLK6
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens Klk6 RNA is up-regulated in splenocytes in a viral capsid protein dependent fashion, using recombinnatly expressed encoding Theiler's murine encephalomyelitis virus TMEV VP1 and VP2 capsid proteins, and in THP-1 monocytes activated by phorbol 12-myristate-13-acetate and lipopolysaccharide up
Mus musculus SJL mice infecteion with Theiler's murine encephalomyelitis virus causes an increase in enzyme expression in the spinal cord and in splenocytes. Klk6 RNA is up-regulated in splenocytes in a viral capsid protein dependent fashion, using recombinnatly expressed encodingTMEVVP1 andVP2 capsid proteins, and in THP-1 monocytes activated by phorbol 12-myristate-13-acetate and lipopolysaccharide up

General Information

General Information Comment Organism
physiological function involvement of Klk6 in chronic progressive demyelinating disease, regulatory activities for kallikrein 6 in the development and progression of central nervous system inflammation and demyelination, overview Mus musculus
physiological function involvement of Klk6 in chronic progressive demyelinating disease, regulatory activities for kallikrein 6 in the development and progression of central nervous system inflammation and demyelination, overview Homo sapiens