Crystallization (Comment) | Organism |
---|---|
purified enzyme bound to inhibitor 9b, X-ray diffraction structure determination and analysis at 1.68 A resolution | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-benzyl 1-[3-[(benzyloxy)carbonyl]phenyl] (2S,3S)-3-(4-hydroxybenzyl)-4-oxoazetidine-1,2-dicarboxylate | - |
Homo sapiens | |
2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-3'-carbamoyl-6-hydroxybiphenyl-3-yl]butanedioic acid | - |
Homo sapiens | |
2-[[4-(aminomethyl)phenyl]carbamoyl]-1-[(1-benzyl-1H-imidazol-2-yl)methyl]-3-hydroxypyridinium | crystal structure analysis of enzyme bound to inhibitor 2-[[4-(aminomethyl)phenyl]carbamoyl]-1-[(1-benzyl-1H-imidazol-2-yl)methyl]-3-hydroxypyridinium, two adjacent beta-barrels connected with several alpha helices and turns, overview | Homo sapiens | |
3-[[N-[[4-(aminomethyl)cyclohexyl]carbonyl]-O-(pyrimidin-2-yl)tyrosyl]amino]benzoic acid | - |
Homo sapiens | |
4,4'-[benzene-1,4-diylbis(methanediyloxy)]bis(3-iodobenzenecarboximidamide) | - |
Homo sapiens | |
4,4'-[pentane-1,5-diylbis(oxy)]bis(3,5-dibromobenzenecarboximidamide) | - |
Homo sapiens | |
4-amino-N-[4-(aminomethyl)phenyl]-2-hydroxybenzamide | - |
Homo sapiens | |
additional information | enzyme inhibitors with a para-amidobenzylanmine P1 group and a 2-hydroxybenzamide scaffold linker identified through virtual screening, The tertiary folding of the enzyme complexed with the inhibitor, overview | Homo sapiens | |
N-[4-(aminomethyl)phenyl]-2-hydroxy-3-methoxybenzamide | - |
Homo sapiens | |
N-[4-(aminomethyl)phenyl]-2-hydroxy-4-methoxybenzamide | - |
Homo sapiens | |
N-[4-(aminomethyl)phenyl]-3-chloro-2-hydroxybenzamide | - |
Homo sapiens | |
N-[4-(aminomethyl)phenyl]-3-[(1-benzyl-1H-imidazol-2-yl)methoxy]pyridine-2-carboxamide | - |
Homo sapiens | |
N-[4-(aminomethyl)phenyl]-4-(dimethylamino)-2-hydroxybenzamide | - |
Homo sapiens | |
N-[4-(aminomethyl)phenyl]-4-chloro-2-hydroxybenzamide | - |
Homo sapiens | |
N-[4-(aminomethyl)phenyl]-4-ethoxy-2-hydroxybenzamide | - |
Homo sapiens | |
N-[4-(aminomethyl)phenyl]-5-tert-butyl-2-hydroxybenzamide | - |
Homo sapiens | |
[(4R,7R,10R,13S,16S)-10-(4-aminobutyl)-18-(benzyloxy)-13,16-bis(hydroxymethyl)-2-methyl-7-(2-methylpropyl)-6,9,12,15,18-pentaoxooctadecan-4-yl]boronic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92876 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
hK6 | - |
Homo sapiens |
kallikrein 6 | - |
Homo sapiens |
KLK6 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0003 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-(aminomethyl)phenyl]-5-tert-butyl-2-hydroxybenzamide | |
0.0018 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-(aminomethyl)phenyl]-3-[(1-benzyl-1H-imidazol-2-yl)methoxy]pyridine-2-carboxamide | |
0.0018 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[[4-(aminomethyl)phenyl]carbamoyl]-1-[(1-benzyl-1H-imidazol-2-yl)methyl]-3-hydroxypyridinium | |
0.0038 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-amino-N-[4-(aminomethyl)phenyl]-2-hydroxybenzamide | |
0.0078 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-(aminomethyl)phenyl]-4-chloro-2-hydroxybenzamide | |
0.0086 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-(aminomethyl)phenyl]-2-hydroxy-3-methoxybenzamide | |
0.0106 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-(aminomethyl)phenyl]-4-(dimethylamino)-2-hydroxybenzamide | |
0.0129 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-(aminomethyl)phenyl]-4-ethoxy-2-hydroxybenzamide | |
0.0135 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-(aminomethyl)phenyl]-3-chloro-2-hydroxybenzamide | |
0.0206 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-(aminomethyl)phenyl]-2-hydroxy-4-methoxybenzamide |