Literature summary for 3.4.21.B10 extracted from

Krenzer, S.; Peterziel, H.; Mauch, C.; Blaber, S.I.; Blaber, M.; Angel, P.; Hess, J.
Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment (2011), J. Invest. Dermatol., 131, 2281-2288.

Search for more literature for 3.4.21.B10

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
keratinocyte	strong expression in keratinocytes located adjacent to benign nevi, primary melanomas, and cutaneous metastatic lesions	Homo sapiens	-
additional information	KLK6 is not detectable in tumor cells of primary and metastatic melanoma and is specifically absent in atypic melanocytes of dysplastic nevi	Homo sapiens	-
stromal cell	strong expression in stromal cells located adjacent to benign nevi, primary melanomas, and cutaneous metastatic lesions	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
kallikrein-related peptidase 6	-	Homo sapiens
KLK6	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	recombinant Klk6 protein significantly induces melanoma cell migration and invasion accompanied by an accelerated intracellular Ca2+ flux. KLK6-induced intracellular Ca2+ flux and tumor cell invasion critically depends on the protease-activated receptor 1	Homo sapiens

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Release 2023.1 (January 2023)