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Literature summary for 3.4.21.B10 extracted from
- Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells (2008), Neoplasia, 10, 140-148.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| caveolin-1 | mediates both KLK6 gene expression and protein secretion | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | KLK6 secretion is reduced by nearly half in the presence of constitutively active SRC531. Pharmacological inhibition of AKT leads to reduced KLK6 expression and KLK6 secretion | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| plasma membrane | KLK6 localizes to caveolin-1-containing membrane fractions in the presence, but not the absence of caveolin-1 | Homo sapiens | 5886 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HCT-116 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| kallikrein 6 | - |
Homo sapiens |
| KLK6 | - |
Homo sapiens |
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