Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antipain | - |
Homo sapiens | |
Aprotinin | - |
Homo sapiens | |
leupeptin | - |
Homo sapiens | |
PMSF | - |
Homo sapiens | |
Soybean trypsin inhibitor | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3 | - |
benzoyl-L-Arg-7-amido-4-methylcoumarin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
proteolytic modification | the enzyme is produced as a preproform. After cleavage of 16 amino acid signal peptide, the proenzyme has a single protease domain with an N-glycosylation site. the proenzyme peptide has the sequence EEQNK | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amyloid plaque | - |
Homo sapiens | - |
brain | predominantly expressed in brain. Located not only in the activated microglia cells but also in amyloid plaque and neurofilament tangles in Alzheimer fluid | Homo sapiens | - |
cerebrospinal fluid | present as the proenzyme | Homo sapiens | - |
Colo-201 cell | - |
Homo sapiens | - |
microglia | - |
Homo sapiens | - |
neurofibrillary tangle | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzoyl-L-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | benzoyl-L-Arg + 7-amino-4-methylcoumarin | - |
? | |
N-alpha-tert-butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-alpha-tert-butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin | - |
? | |
N-alpha-tert-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-alpha-tert-butyloxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin | - |
? | |
N-alpha-tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-alpha-tert-butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin | - |
? |