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Literature summary for 3.4.21.B10 extracted from

  • Yamaguchi, N.
    Neurosin or human kallikrein 6 (2004), Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press, 2, 1585-1587.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
antipain
-
Homo sapiens
Aprotinin
-
Homo sapiens
leupeptin
-
Homo sapiens
PMSF
-
Homo sapiens
Soybean trypsin inhibitor
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3
-
benzoyl-L-Arg-7-amido-4-methylcoumarin
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens
proteolytic modification the enzyme is produced as a preproform. After cleavage of 16 amino acid signal peptide, the proenzyme has a single protease domain with an N-glycosylation site. the proenzyme peptide has the sequence EEQNK Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
amyloid plaque
-
Homo sapiens
-
brain predominantly expressed in brain. Located not only in the activated microglia cells but also in amyloid plaque and neurofilament tangles in Alzheimer fluid Homo sapiens
-
cerebrospinal fluid present as the proenzyme Homo sapiens
-
Colo-201 cell
-
Homo sapiens
-
microglia
-
Homo sapiens
-
neurofibrillary tangle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-L-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens benzoyl-L-Arg + 7-amino-4-methylcoumarin
-
?
N-alpha-tert-butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens N-alpha-tert-butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
?
N-alpha-tert-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens N-alpha-tert-butyloxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
-
?
N-alpha-tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens N-alpha-tert-butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
?