Any feedback?
Literature summary for 3.4.21.B1 extracted from
- Interaction of factor VII activating protease (FSAP) with neutrophil extracellular traps (NETs) (2018), Thromb. Res., 161, 36-42 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q14520 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| histone + H2O | - |
Homo sapiens | ? | - |
? |  |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | phorbol ester-mediated neutrophil extracellular trap (NET) formation is marginally stimulated by FSAP. Plasma-derived FSAP as well as exogenous FSAP binds to NET, and FSAP and NETs colocalize in coronary thrombi from patients with acute myocardial infarction. No activation of pro-FSAP by NETs is evident, but after disintegration of NETs with DNase, a robust activation of pro-FSAP, due to release of histones from nucleosomes, is detected. The released histones are in turn degraded by FSAP. Histone cytotoxicity towards endothelial cells is neutralized by FSAP more potently than by activated protein C | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
