Literature summary for 3.4.21.B1 extracted from

Sperling, C.; Maitz, M.F.; Grasso, S.; Werner, C.; Kanse, S.M.
A positively charged surface triggers coagulation activation through factor VII activating protease (FSAP) (2017), ACS Appl. Mater. Interfaces, 9, 40107-40116 .

Search for more literature for 3.4.21.B1

Activating Compound

Activating Compound	Comment	Organism	Structure
poly-L-lysine	FSAP is exclusively activated by the positively charged surfaces polyethylenimine and poly-L-lysine	Homo sapiens
polyethylenimine	FSAP is exclusively activated by the positively charged surfaces polyethylenimine and poly-L-lysine	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q14520	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Homo sapiens	-

General Information

General Information	Comment	Organism
metabolism	FSAP is exclusively activated by the positively charged surfaces polyethylenimine and poly-L-lysine, not by the negatively charged glass or self-assembled monolayer with carboxyl group termination or uncharged (Teflon AF) surfaces. Activation is concomitant with coagulation. A contact phase inhibitor diminishes coagulation to background levels for all surfaces except polyethylenimine	Homo sapiens

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Release 2023.1 (January 2023)