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Literature summary for 3.4.21.B1 extracted from

  • Sidelmann, J.J.; Skouby, S.O.; Kluft, C.; Winkler, U.; Vitzthum, F.; Schwarz, H.; Gram, J.; Jespersen, J.
    Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo (2011), Thromb. Res., 128, e67-e72.
    View publication on PubMed
Search for more literature for 3.4.21.B1

Protein Variants

Protein Variants Comment Organism
additional information the 1601GA genotype of the 1601 G/A polymorphism in the factor VII-activating protease gene expresses reduced levels of an alloenzyme with reduced pro-fibrinolytic activity. The relative increase in FSAP activity is significantly higher in women carrying the 1601GG genotype (63%) than in women carrying 1601GA genotype (50%) and is associated with an increased activation of factor VII Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor VII + H2O Homo sapiens
-
 activated factor VII + ?
-
 ?
Fibrinogen + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor VII + H2O
-
 Homo sapiens activated factor VII + ?
-
 ?
Fibrinogen + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
factor VII-activating protease
-
 Homo sapiens
FSAP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens oral contraceptive use with preparartions containing ethinylestradiol, levonorgestrel, desogestrel, gestodene, and norgestimate increases the plasma measures of factor VII-activating protease up

General Information

General Information Comment Organism
physiological function factor VII-activating protease has potential effects on hemostasis Homo sapiens