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Literature summary for 3.4.21.B1 extracted from

  • Kanse, S.M.; Declerck, P.J.; Ruf, W.; Broze, G.; Etscheid, M.
    Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor (2012), Arterioscler. Thromb. Vasc. Biol., 32, 427-433.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B1

Inhibitors

Inhibitors Comment Organism Structure
Aprotinin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor VII + H2O Homo sapiens
-
 activated factor VII + ?
-
 ?
platelet-derived growth factor-BB + H2O Homo sapiens the enzyme inhibits platelet-derived growth factor-BB ?
-
 ?
prourokinase + H2O Homo sapiens
-
 urokinase + ?
-
 ?
tissue factor pathway inhibitor + H2O Homo sapiens the enzyme inhibits tissue factor pathway inhibitor, cleavage occurs between kringle domains K1 and K2 (Lys86-Thr87), as well as in the active site of K2 (Arg107-Gly108) and K3 (Arg199-Ala200) domains ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor VII + H2O
-
 Homo sapiens activated factor VII + ?
-
 ?
platelet-derived growth factor-BB + H2O the enzyme inhibits platelet-derived growth factor-BB Homo sapiens ?
-
 ?
prourokinase + H2O
-
 Homo sapiens urokinase + ?
-
 ?
tissue factor pathway inhibitor + H2O the enzyme inhibits tissue factor pathway inhibitor, cleavage occurs between kringle domains K1 and K2 (Lys86-Thr87), as well as in the active site of K2 (Arg107-Gly108) and K3 (Arg199-Ala200) domains Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
factor VII-activating protease
-
 Homo sapiens
FSAP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction the variant Marburg I polymorphism results in low enzymatic activity and is associated with an enhanced risk of carotid stenosis and stroke Homo sapiens
physiological function the enzyme regulates hemostasis- and remodeling-associated processes in the vasculature Homo sapiens