Cloned (Comment) | Organism |
---|---|
expression of recombinant FSAP-isoforms in HEK-293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G534E | the naturally occurring G534E-variant exhibits reduced proteolytic activity | Homo sapiens |
additional information | the DEGF-3 mutant shows diminished binding to and activation by heparin | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | regulation of FSAP activity is dependent on its EGF-3 domain and over-expression of active variants induces cell death | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q14520 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-pyroglutamylglycyl-L-arginine-p-nitroanilide + H2O | - |
Homo sapiens | L-pyroglutamylglycyl-L-arginine + p-nitroaniline | - |
? | |
additional information | regulation of FSAP activity is dependent on its EGF-3 domain and over-expression of active variants induces cell death | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor VII activating protease | - |
Homo sapiens |
FSAP | - |
Homo sapiens |