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Literature summary for 3.4.21.B1 extracted from

  • Muhl, L.; Nykjaer, A.; Wygrecka, M.; Monard, D.; Preissner, K.T.; Kanse, S.M.
    Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP (2007), Biochem. J., 404, 191-196.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B1

Inhibitors

Inhibitors Comment Organism Structure
Protease nexin-1 inhibits FSAP enzymatic activity, which leads to the loss of the inhibitory effect of FSAP on platelet-derived growth factor-BB-mediated DNA synthesis and mitogen-activated protein kinase phosphorylation in vascular smooth-muscle cells. The FSAP-protease nexin-1 complex binds to the low-density lipoprotein receptor-related protein and is subsequently internalized. This binding is inhibited by receptor associated protein as well as heparin. The FSAP-inhibitor complexes are internalized via low-density lipoprotein receptor-related protein without influencing the platelet-derived growth factor-BB signal transduction pathway Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-isoleucyl-L-prolyl-L-arginine-p-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
platelet-derived growth factor-BB + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
factor VII-activating protease
-
 Homo sapiens
FSAP
-
 Homo sapiens