Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.B1 extracted from

  • Parahuleva, M.S.; Kanse, S.M.; Parviz, B.; Barth, A.; Tillmanns, H.; Bohle, R.M.; Sedding, D.G.; Hoelschermann, H.
    Factor Seven Activating Protease (FSAP) expression in human monocytes and accumulation in unstable coronary atherosclerotic plaques (2008), Atherosclerosis, 196, 164-171.
    View publication on PubMed
Search for more literature for 3.4.21.B1

Activating Compound

Activating Compound Comment Organism Structure
IL-6 stimulates FSAP mRNA expression 5.5fold at 24 h Homo sapiens
IL-alpha stimulates FSAP mRNA expression 4fold at 24 h Homo sapiens
LPS stimulates FSAP mRNA expression 6fold after 1 h, reaching a plateau at 2 h (7fold stimulation) and gradually decreases until returning to the base level at 24 h Homo sapiens
additional information TNF-alpha has no effect Homo sapiens

Application

Application Comment Organism
medicine FSAP accumulation in coronary atherosclerotic lesions, is due to either local synthesis by monocytes/macrophages, or uptake from the plasma due to plaque hemorrhage. Higher expression of FSAP in unstable plaques may destabilize plaque through reducing vascular smooth muscle cell proliferation/migration and altering the hemostatic balance Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
64000
-
 metabolic labelling and immunoprecipitation under non reducing conditions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery FSAP expression in stable and especially unstable coronary atherosclerotic lesions. FSAP mainly in inflammatory regions within the shoulders of the plaque surounding or located within the lipid core that is infiltrated by macrophages. Some FSAP present within fibrotic regions in the cap of the plaque. Tight colocalization of FSAP and uPA-presenting cells in all plaques. Colocalization also with CD11b/CD68. Also present in hypocellular- and lipid rich areas of atherosclerotic plaques in internal mammary arteries, absent from normal non-atherosclerotic arteries Homo sapiens
-
liver
-
 Homo sapiens
-
lymphocyte weak expression Homo sapiens
-
macrophage highly expressed in macrophages of atherosclerotic lesions Homo sapiens
-
monocyte
-
 Homo sapiens
-
additional information weak expression in dentritic cells, absent from vascular smooth muscle cells and HUVEC cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-uPa + H2O
-
 Homo sapiens uPa
-
 ?

Synonyms

Synonyms Comment Organism
factor seven activating protease
-
 Homo sapiens
FSAP
-
 Homo sapiens