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Literature summary for 3.4.21.B1 extracted from
- Factor VII activating protease (FSAP): a novel protease in hemostasis (2002), Biol. Chem., 383, 1119-1124.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| heparin | supports autoactivation | Homo sapiens |  |
| poly-L-lysine | - |
Homo sapiens | |
| urokinase | potential physiological activator | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha2-antiplasmin | potent inhibitor | Homo sapiens | |
| antithrombin | potent inhibitor only in presence of heparin | Homo sapiens | |
| Aprotinin | - |
Homo sapiens | |
| C1-inhibitor | potent inhibitor | Homo sapiens | |
| Ca2+ | stabilizes proenzyme | Homo sapiens | |
| inter-alpha-trypsin inhibitor | potent inhibitor | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 64000 | - |
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | role in hemostasis is likely | ? | - |
? | |
| Protein + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor V + H2O | - |
Homo sapiens | ? | - |
? | |
| factor VII + H2O | - |
Homo sapiens | ? | - |
? | |
| factor VIII + H2O | - |
Homo sapiens | ? | - |
? | |
| Fibrinogen + H2O | - |
Homo sapiens | ? | - |
? | |
| Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| kininogen + H2O | - |
Homo sapiens | bradykinin + ? | - |
? | |
| additional information | role in hemostasis is likely | Homo sapiens | ? | - |
? | |
| Protein + H2O | - |
Homo sapiens | ? | - |
? | |
| prourokinase + H2O | - |
Homo sapiens | ? | - |
? | |
| transcription factor of amyloid beta protein precursor + H2O | - |
Homo sapiens | ? | - |
? | |
| Vitronectin + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor seven activating protease | - |
Homo sapiens |
| FSAP | - |
Homo sapiens |
| PHBP | - |
Homo sapiens |
| PHBSP | - |
Homo sapiens |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | - |
- |
4.9 |
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