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Literature summary for 3.4.21.98 extracted from

  • Landro, J.A.; Raybuck, S.A.; Luong, Y.P.C.; OæMalley, E.T.; Harbeson, S.L.; Morgenstern, K.A.; Rao, G.; Livingston, D.J.
    Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping (1997), Biochemistry, 36, 9340-9348.
    View publication on PubMed
Search for more literature for 3.4.21.98

Activating Compound

Activating Compound Comment Organism Structure
NS4A enhances the activity of NS3 protease in all cleavages via the formation of an NS3/NS4A Hepacivirus C

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.032
-
 EDVV-4-aminobutyryl-CSMSY presence of cofactor Hepacivirus C
0.16
-
 DEMEECSQHLPYI presence of cofactor Hepacivirus C
0.27
-
 EDVV-4-aminobutyryl-CSMSY absence of cofactor Hepacivirus C
0.805
-
 DEMEECSQHLPYI absence of cofactor Hepacivirus C
1.01
-
 Glu-Asp-Val-Val-4-aminobutyryl-Cys-p-nitroanilide presence of cofactor Hepacivirus C
1.08
-
 Glu-Asp-Val-Val-4-aminobutyryl-Cys-p-nitroanilide absence of cofactor Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DEMEECSQHLPYI + H2O
-
 Hepacivirus C DEMEEC + SQHLPYI
-
 ?
ECTTPCSGSWIRD + H2O
-
 Hepacivirus C ECTTPC + SGSWIRD
-
 ?
EDVV-4-aminobutyryl-CSMSY + H2O
-
 Hepacivirus C EDVV-4-aminobutyryl-C + SMSY
-
 ?
Glu-Asp-Val-Val-4-aminobutyryl-Cys-p-nitroanilide + H2O
-
 Hepacivirus C Glu-Asp-Val-Val-4-aminobutyryl-Cys + 4-nitroaniline
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.012
-
 Glu-Asp-Val-Val-4-aminobutyryl-Cys-p-nitroanilide absence of cofactor Hepacivirus C
0.05
-
 DEMEECSQHLPYI absence of cofactor Hepacivirus C
0.18
-
 EDVV-4-aminobutyryl-CSMSY absence of cofactor Hepacivirus C
0.2
-
 Glu-Asp-Val-Val-4-aminobutyryl-Cys-p-nitroanilide presence of cofactor Hepacivirus C
0.243
-
 DEMEECSQHLPYI presence of cofactor Hepacivirus C
0.6
-
 EDVV-4-aminobutyryl-CSMSY presence of cofactor Hepacivirus C