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Literature summary for 3.4.21.98 extracted from

  • Llinas-Brunet, M.; Bailey, M.; Fazal, G.; Goulet, S.; Halmos, T.; Laplante, S.; Maurice, R.; Poirier, M.; Poupart, M.A.; Thibeault, D.; Wernic, D.; Lamarre, D.
    Peptide-based inhibitors of the hepatitis C virus serine protease (1998), Bioorg. Med. Chem. Lett., 8, 1713-1718.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NS4A enhances the activity of NS3 protease in all cleavages via the formation of an NS3/NS4A Hepacivirus C

Application

Application Comment Organism
pharmacology the viral protease may be a target for antiviral drugs Hepacivirus C

Inhibitors

Inhibitors Comment Organism Structure
Ac-DDIVPC-OH 0.04 mM, 50% inhibition Hepacivirus C
Ac-DVIVPC-OH 0.0075 mM, 50% inhibition Hepacivirus C
DDIVPC-OH 0.071 mM, 50% inhibition Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
non-structural protein NS5B of hepatitis C virus + H2O
-
Hepacivirus C ? + DDIVPC-OH N-terminal hexapeptide ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0075
-
Ac-DVIVPC-OH
-
Hepacivirus C
0.04
-
Ac-DDIVPC-OH
-
Hepacivirus C
0.071
-
DDIVPC-OH
-
Hepacivirus C