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Literature summary for 3.4.21.98 extracted from

  • Naeem, A.; Waheed, Y.
    Sequence analysis of hepatitis C virus nonstructural protein 3-4A serine protease and prediction of conserved B and T cell epitopes (2017), Biomed. Rep., 7, 563-566 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.98

Application

Application Comment Organism
drug development the epitopes B1, B8 and B9 are predicted to be ideal candidates for B-cell-based vaccine and are over 95% conserved across six major HCV genotypes. Determination of position and sequences of the peptides that may be used for development of peptide vaccines, overview Hepacivirus C

Cloned(Commentary)

Cloned (Comment) Organism
RNA sequence determination Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
 six major HCV genotypes
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
nonstructural protein 3-4A serine protease
-
 Hepacivirus C
nonstructural protein 3-4Agene
-
 Hepacivirus C
NS34Agene
-
 Hepacivirus C
NS3?4A
-
 Hepacivirus C

General Information

General Information Comment Organism
evolution the hepatitis C virus (HCV) is a plus stranded RNA virus belonging to the Flaviviridae family. Despite the high mutation rate of HCV, the functionally important residues are highly conserved. These include residues that form the catalytic triad (His57, Asp81, and Ser139), the S1 and S6 pocket, zinc-binding site (Cys97, Cys99, Cys145, and His149) and the substrate binding groove. The epitopes B1, B8 and B9 are over 95% conserved across six major HCV genotypes Hepacivirus C
additional information the location of possible B- and T-cell epitopes are predicted in the HCV NS3-4A consensus sequence Hepacivirus C