Literature summary for 3.4.21.98 extracted from

Brenndoerfer, E.D.; Brass, A.; Karthe, J.; Ahlen, G.; Bode, J.G.; Saellberg, M.
Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy (2014), J. Immunol., 192, 1671-1680.

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Application

Application	Comment	Organism
medicine	cleavage of T cell protein tyrosine phosphatase by NS3/4A induces a shift of the intrahepatic immune response toward a nonantiviral Th2-dominated immunity	Hepacivirus C

Inhibitors

Inhibitors	Comment	Organism	Structure
ribavirin	-	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	-	-

General Information

General Information	Comment	Organism
physiological function	intrahepatic expression of viral protease NS3/4A makes mice resistant to TNF-alpha-induced liver damage and causes an alteration of the intrahepatic cytokine IFN-g and IL-10 and chemokine CCL3, CCL17, CCL22, CXCL9, and CXCL11 profiles toward an anti-inflammatory state. The number of intrahepatic Th1 cells and IFN-g+ T cells in NS3/4A transgenic mice decreases, whereas the amount of Th2 cells increases. The NS3/4A-mediated effects are reversed by ribavirin treatment	Hepacivirus C

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Release 2023.1 (January 2023)