Literature summary for 3.4.21.98 extracted from

Aparicio, E.; Franco, S.; Parera, M.; Andres, C.; Tural, C.; Clotet, B.; Martinez, M.A.
Complexity and catalytic efficiency of hepatitis C virus (HCV) NS3 and NS4A protease quasispecies influence responsiveness to treatment with pegylated interferon plus ribavirin in HCV/HIV-coinfected patients (2011), J. Virol., 85, 5961-5969.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
caspase recruitment domain adaptor-inducing IFN-beta (Cardif) + H2O	Hepacivirus C	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
caspase recruitment domain adaptor-inducing IFN-beta (Cardif) + H2O	-	Hepacivirus C	?	-	?

Synonyms

Synonyms	Comment	Organism
NS3/4A protease	-	Hepacivirus C

General Information

General Information	Comment	Organism
physiological function	the impact of NS3/4A protease activity and quasispecies complexity on virus clearance after IFN-based therapy is examined in HCV-HIV-1-coinfected patients: NS3/4A protease efficiency in cleaving caspase recruitment domain adaptor-inducing IFN-beta (Cardif) may be associated with the pegIFN-RBV treatment response	Hepacivirus C

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Release 2023.1 (January 2023)