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Literature summary for 3.4.21.98 extracted from

  • Peres-da-Silva, A.; de Almeida, A.J.; Lampe, E.
    Mutations in hepatitis C virus NS3 protease domain associated with resistance to specific protease inhibitors in antiviral therapy naive patients (2010), Arch. Virol., 155, 807-811.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
T54A the mutation is associated with low to medium levels of resistance to the HCV NS3-4A serine protease inhibitor telaprevir (VX-950) Hepacivirus C
T54S the mutation is associated with low to medium levels of resistance to the HCV NS3-4A serine protease inhibitor telaprevir (VX-950) Hepacivirus C
V36A the mutation is associated with low to medium levels of resistance to the HCV NS3-4A serine protease inhibitor telaprevir (VX-950) Hepacivirus C
V36G the mutation is associated with low to medium levels of resistance to the HCV NS3-4A serine protease inhibitor telaprevir (VX-950) Hepacivirus C
V36L the mutation is associated with low to medium levels of resistance to the HCV NS3-4A serine protease inhibitor telaprevir (VX-950) Hepacivirus C
V36M the mutation is associated with low to medium levels of resistance to the HCV NS3-4A serine protease inhibitor telaprevir (VX-950) Hepacivirus C

Inhibitors

Inhibitors Comment Organism Structure
STAT-C
-
Hepacivirus C
telaprevir VX-950 Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
genotypes 1a, 1b, and 3a
-

Synonyms

Synonyms Comment Organism
NS3 protease
-
Hepacivirus C
NS3-4A serine protease
-
Hepacivirus C