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Literature summary for 3.4.21.98 extracted from
- Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms (2006), Proc. Natl. Acad. Sci. USA, 103, 8499-8504.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | NS3 protease blunts the ability of hepatitis C virus to induce IFN-alpha promoter activity by proteolytically cleaving MAVS/IPS-1. Hepatitis C virus blocks the synthetic dsRNA-induced signaling pathway at a point upstream of MAVS/IPS-1 by an NS3-independent mechanism | Hepacivirus C |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BILN2061 | NS3 protease inhibitor, fully restores MAVS/IPS-1-dependent IFN-alpha promoter activity in Hepatitis C virus-infected cells | Hepacivirus C |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Hepacivirus C | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| MAVS/IPS-1 + H2O | - |
Hepacivirus C | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| nonstructural protein 3 | - |
Hepacivirus C |
| NS3 protease | - |
Hepacivirus C |
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