Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
assembly protein precursor of cytomegalovirus + H2O | Human betaherpesvirus 5 | the enzyme is essential for virus replication and functions during capsid assembly from pAP, i.e. assembly protein precursor | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human betaherpesvirus 5 | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the proteinase is synthesized as an enzymatiacally active precursor that undergoes several autoproteolytic cleavages. Two of these are common in all herpes group viruses, one occurs toward the carboxyl end of the precursor, i.e. M-site, and the other near the middle at the R-site. The R-site cleavage divides the precusor into assemblin and a nonproteolytic carboxyl half. CMV proteinase undergoes a third autoproteolytic cleavage that divides assemblin into approximately equal-size An and Ac subunits. None of these cleavages is absolutely necessary for enzyme activity | Human betaherpesvirus 5 |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
assembly protein precursor of cytomegalovirus + H2O | the enzyme is essential for virus replication and functions during capsid assembly from pAP, i.e. assembly protein precursor | Human betaherpesvirus 5 | ? | - |
? |