Application | Comment | Organism |
---|---|---|
medicine | targeting prodrugs for activation by a specific protease encoded by the infectious HCMV pathogen may be achievable. Dipeptide prodrug of ganciclovir, acetyl-L-Gln-L-Ala-ganciclover, is a potential selective prodrug candidate | Human betaherpesvirus 5 |
Protein Variants | Comment | Organism |
---|---|---|
A143T/A144T | mutant displays better stability than wild-type and has esterase activity toward specific small ester compounds, e.g., Boc-L-Ala-4-nitrophenol | Human betaherpesvirus 5 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human betaherpesvirus 5 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-L-Gln-L-Ala-gancyclovir + H2O | dipeptide prodrugs of ganciclovir | Human betaherpesvirus 5 | acetyl-L-Gln-L-Ala + ganciclovir | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HCMV protease | - |
Human betaherpesvirus 5 |