Crystallization (Comment) | Organism |
---|---|
in complex with inhibitors 3_4_21-97_3-cp2 and 3_4_21-97_3-cp3 | Human betaherpesvirus 5 |
in complex with inhibitors 3_4_21-97_3-cp2 and 3_4_21-97_3-cp3 | Human gammaherpesvirus 4 |
in complex with inhibitors 3_4_21-97_3-cp2 and 3_4_21-97_3-cp3 | Human gammaherpesvirus 8 |
in complex with inhibitors {N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide and N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | Human alphaherpesvirus 2 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | compound binds to the dimer interface of the protease and disrupts dimerization | Human alphaherpesvirus 2 | |
N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | compound binds to the dimer interface of the protease and disrupts dimerization | Human betaherpesvirus 5 | |
N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | compound binds to the dimer interface of the protease and disrupts dimerization | Human gammaherpesvirus 4 | |
N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | compound binds to the dimer interface of the protease and disrupts dimerization | Human gammaherpesvirus 8 | |
N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | compound binds to the dimer interface of the protease and disrupts dimerization | Human alphaherpesvirus 2 | |
N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | compound binds to the dimer interface of the protease and disrupts dimerization | Human betaherpesvirus 5 | |
N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | compound binds to the dimer interface of the protease and disrupts dimerization | Human gammaherpesvirus 4 | |
N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | compound binds to the dimer interface of the protease and disrupts dimerization | Human gammaherpesvirus 8 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human alphaherpesvirus 2 | - |
- |
- |
Human betaherpesvirus 5 | - |
- |
- |
Human gammaherpesvirus 4 | - |
- |
- |
Human gammaherpesvirus 8 | - |
Kaposi's sarcoma-associated herpesvirus | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.001 | - |
pH 8.0, temperature not specified in the publication | Human gammaherpesvirus 8 | N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | |
0.0037 | - |
pH 8.0, temperature not specified in the publication | Human gammaherpesvirus 8 | N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | |
0.004 | - |
pH 8.0, temperature not specified in the publication | Human gammaherpesvirus 4 | N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | |
0.0047 | - |
pH 8.0, temperature not specified in the publication | Human betaherpesvirus 5 | N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | |
0.019 | - |
pH 8.0, temperature not specified in the publication | Human gammaherpesvirus 4 | N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | |
0.0388 | - |
pH 8.0, temperature not specified in the publication | Human betaherpesvirus 5 | N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | |
0.094 | - |
pH 8.0, temperature not specified in the publication | Human alphaherpesvirus 2 | N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide | |
0.367 | - |
pH 8.0, temperature not specified in the publication | Human alphaherpesvirus 2 | N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide |