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Literature summary for 3.4.21.97 extracted from

  • Gable, J.; Lee, G.; Jaishankar, P.; Hearn, B.; Waddling, C.; Renslo, A.; Craik, C.
    Broad-spectrum allosteric inhibition of herpesvirus proteases (2014), Biochemistry, 53, 4648-4660.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitors 3_4_21-97_3-cp2 and 3_4_21-97_3-cp3 Human betaherpesvirus 5
in complex with inhibitors 3_4_21-97_3-cp2 and 3_4_21-97_3-cp3 Human gammaherpesvirus 4
in complex with inhibitors 3_4_21-97_3-cp2 and 3_4_21-97_3-cp3 Human gammaherpesvirus 8
in complex with inhibitors {N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide and N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide Human alphaherpesvirus 2

Inhibitors

Inhibitors Comment Organism Structure
N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide compound binds to the dimer interface of the protease and disrupts dimerization Human alphaherpesvirus 2
N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide compound binds to the dimer interface of the protease and disrupts dimerization Human betaherpesvirus 5
N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide compound binds to the dimer interface of the protease and disrupts dimerization Human gammaherpesvirus 4
N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide compound binds to the dimer interface of the protease and disrupts dimerization Human gammaherpesvirus 8
N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide compound binds to the dimer interface of the protease and disrupts dimerization Human alphaherpesvirus 2
N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide compound binds to the dimer interface of the protease and disrupts dimerization Human betaherpesvirus 5
N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide compound binds to the dimer interface of the protease and disrupts dimerization Human gammaherpesvirus 4
N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide compound binds to the dimer interface of the protease and disrupts dimerization Human gammaherpesvirus 8

Organism

Organism UniProt Comment Textmining
Human alphaherpesvirus 2
-
-
-
Human betaherpesvirus 5
-
-
-
Human gammaherpesvirus 4
-
-
-
Human gammaherpesvirus 8
-
Kaposi's sarcoma-associated herpesvirus
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.001
-
pH 8.0, temperature not specified in the publication Human gammaherpesvirus 8 N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide
0.0037
-
pH 8.0, temperature not specified in the publication Human gammaherpesvirus 8 N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide
0.004
-
pH 8.0, temperature not specified in the publication Human gammaherpesvirus 4 N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide
0.0047
-
pH 8.0, temperature not specified in the publication Human betaherpesvirus 5 N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide
0.019
-
pH 8.0, temperature not specified in the publication Human gammaherpesvirus 4 N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide
0.0388
-
pH 8.0, temperature not specified in the publication Human betaherpesvirus 5 N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide
0.094
-
pH 8.0, temperature not specified in the publication Human alphaherpesvirus 2 N-[2-benzyl-4-[(methylsulfonyl)carbamoyl]phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide
0.367
-
pH 8.0, temperature not specified in the publication Human alphaherpesvirus 2 N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide