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Literature summary for 3.4.21.94 extracted from

  • Tang, S.S.; Zhang, J.H.; Liu, H.X.; Zhou, D.; Qi, R.
    Pro-protein convertase-2/carboxypeptidase-E mediated neuropeptide processing of RGC-5 cell after in vitro ischemia (2009), Neurosci. Bull., 25, 7-14.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.94

Inhibitors

Inhibitors Comment Organism Structure
additional information oxygen and glucose deprivation inhibit the PC2 activity, the pro-PC2 maturation, and thus the neuropeptide pro-protein processing system Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the pro-protein convertase-2, PC2, needs to activated from a pro-PC2 form to the active PC2 form Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
RGC-5 cell ischemic retinal ganglion cells Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
PC2
-
 Rattus norvegicus
pro-protein convertase-2
-
 Rattus norvegicus
pro-protein convertase-2/carboxypeptidase-E
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus proPC2 levels in ischemic RCG-5 cells gradually increase with ischemia and cell death after oxygen and glucose deprivation, while PC2 activity decreasesoverview up

General Information

General Information Comment Organism
physiological function PC2 is required for the neuropeptide pro-protein processing system Rattus norvegicus