BRENDA - Enzyme Database
show all sequences of 3.4.21.94

Prohormone convertases 1/3, 2, furin and protein 7B2 (Secretogranin V) in endocrine cells of the human pancreas

Portela-Gomes, G.M.; Grimelius, L.; Stridsberg, M.; Regul. Pept. 146, 117-124 (2008)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
endocrine pancreas
insulin cells and glucagon cells express PC2, few somatostatin cells contain PC2, is absent from pancreatic polypeptide cells. Colocalization of PC2 with PC1/3, furin and 7B2
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
additional information
PC2 may be important in insulin and glucagon cells for processing of hormone and other protein precursors
682808
Homo sapiens
?
-
-
-
-
Synonyms
Synonyms
Commentary
Organism
PC2
-
Homo sapiens
prohormone convertase 2
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
endocrine pancreas
insulin cells and glucagon cells express PC2, few somatostatin cells contain PC2, is absent from pancreatic polypeptide cells. Colocalization of PC2 with PC1/3, furin and 7B2
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
additional information
PC2 may be important in insulin and glucagon cells for processing of hormone and other protein precursors
682808
Homo sapiens
?
-
-
-
-
Other publictions for EC 3.4.21.94
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
753499
Nakamoto
Regulation of prohormone conv ...
Mus musculus
Eur. J. Pharmacol.
762
459-463
2015
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1
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1
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753696
Tein
Prohormone convertase 2 activ ...
Mus musculus
Front. Mol. Neurosci.
8
45
2015
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731672
Hiramoto
Ultraviolet B irradiation of t ...
Mus musculus
Clin. Exp. Dermatol.
38
71-76
2013
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1
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731759
Chen
Mutant PAX6 downregulates proh ...
Mus musculus
Exp. Biol. Med. (Maywood)
238
1259-1264
2013
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1
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1
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732571
Zhan
Dynamic changes in proprotein ...
Rattus norvegicus
Neural Regen. Res.
8
83-89
2013
-
1
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2
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731872
Tangprasittipap
Structure and expression of a ...
Penaeus monodon
Gen. Comp. Endocrinol.
178
185-193
2012
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1
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3
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1
1
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1
1
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1
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717856
Helwig
Dynamic modulation of PC2-medi ...
Mus musculus
J. Biol. Chem.
286
42504-42513
2011
1
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1
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1
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1
1
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709603
Zhang
Neuropeptidomic analysis estab ...
Mus musculus
J. Neurochem.
112
1168-1179
2010
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1
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7
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7
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1
1
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717906
Iino
Possible relevance between pro ...
Homo sapiens
J. Clin. Endocrinol. Metab.
95
4003-4011
2010
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1
1
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-
700298
Kowalska
Synthetic small-molecule proho ...
Mus musculus
Mol. Pharmacol.
75
617-625
2009
-
-
1
-
-
-
8
-
-
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-
1
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1
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1
1
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1
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7
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1
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8
7
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1
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1
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1
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708778
Cummins
Expression of prohormone conve ...
Haliotis asinina
Int. J. Dev. Biol.
53
1081-1088
2009
-
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1
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3
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4
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4
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1
1
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709250
Zhan
Defective neuropeptide process ...
Rattus norvegicus
J. Cereb. Blood Flow Metab.
29
698-706
2009
-
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1
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1
2
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3
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5
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2
1
1
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1
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1
2
2
1
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710101
Tang
Pro-protein convertase-2/carbo ...
Rattus norvegicus
Neurosci. Bull.
25
7-14
2009
-
-
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1
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1
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1
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1
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1
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1
1
1
1
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682808
Portela-Gomes
Prohormone convertases 1/3, 2, ...
Homo sapiens
Regul. Pept.
146
117-124
2008
-
-
-
-
-
-
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-
1
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1
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1
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1
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700473
Espinosa
Differential regulation of pro ...
Rattus norvegicus
Neuroscience
156
788-799
2008
-
1
-
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-
-
-
-
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1
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1
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677957
Lee
Processing and trafficking of ...
Mus musculus
Biochem. Biophys. Res. Commun.
355
825-829
2007
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1
-
1
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1
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1
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1
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683932
Billova
Immunohistochemical expression ...
Rattus norvegicus
Neuroscience
147
403-418
2007
-
1
-
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1
-
2
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1
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5
-
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1
1
2
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1
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1
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5
-
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1
1
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686303
Wideman
A switch from prohormone conve ...
Mus musculus
Diabetes
56
2744-2752
2007
-
1
1
-
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-
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1
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1
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1
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1
1
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1
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1
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689018
Leak
Association of the proprotein ...
Homo sapiens
Mol. Genet. Metab.
92
145-150
2007
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1
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1
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689214
Marandi
Proprotein convertases 1 and 2 ...
Rattus norvegicus
Neurosci. Lett.
420
198-203
2007
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669436
Ugleholdt
Prohormone convertase 1/3 is e ...
Mus musculus
J. Biol. Chem.
281
11050-11057
2006
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1
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1
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1
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2
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1
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686302
Marzban
Impaired NH2-terminal processi ...
Mus musculus
Diabetes
55
2192-2201
2006
-
1
1
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1
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1
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1
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1
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1
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688466
Kitabgi
Prohormone convertases differe ...
Homo sapiens, Mus musculus, Rattus norvegicus
J. Mol. Med.
84
628-634
2006
-
-
1
-
1
-
1
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3
-
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11
-
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3
-
3
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1
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11
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3
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688525
Pan
The role of prohormone convert ...
Mus musculus
J. Neurochem.
98
1763-1777
2006
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688526
Husson
Defective processing of neurop ...
Caenorhabditis elegans, Caenorhabditis elegans N2
J. Neurochem.
98
1999-2012
2006
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1
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17
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