Literature summary for 3.4.21.93 extracted from

Blanco, E.H.; Peinado, J.R.; Martin, M.G.; Lindberg, I.
Biochemical and cell biological properties of the human prohormone convertase 1/3 Ser357Gly mutation: a PC1/3 hypermorph (2014), Endocrinology, 155, 3434-3447.

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Protein Variants

Protein Variants	Comment	Organism
S357G	mutant represents a prohormone convertase PC1/3 hypermorph. Mutant protein exhibits a lower calcium dependence, a higher pH optimum, and a higher resistance to peptide inhibitors than the wild-type enzyme. The mutant exhibits increased cleavage to the C-terminally truncated form, and kinetic parameters of the full-length and truncated mutant enzymes are also altered. The S357G mutation broadens the specificity of the enzyme, it displays proprotein convertase 2-like specificity on the substrate proCART, the precursor of the cocaine- and amphetamine regulated transcript neuropeptide. The mutant enzyme possesses unusual processing activity that may significantly change the profile of circulating peptide hormones	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P29120	-	-

Synonyms

Synonyms	Comment	Organism
Neuroendocrine convertase 1	-	Homo sapiens
PC 1/3	-	Homo sapiens

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Release 2023.1 (January 2023)