Application | Comment | Organism |
---|---|---|
medicine | transplantation of PC1/3-expressing alpha-cells prevents streptozotocin-induced hyperglycemia by preserving beta-cell area and islet morphology, possibly via stimulating beta-cell replication. Expression of PC1/3 rather than PC2 in alpha-cells induces glucagon-like peptide 1 and glucagon-like peptide 2 production and converts the alpha-cell from a hyperglycemia-promoting cell to one that lowers blood glucose levels. Alteration of proglucagon processing in the alpha-cell may be therapeutically useful in the context of type 1 diabetes | Mus musculus |
Cloned (Comment) | Organism |
---|---|
transplantation of encapsulated PC2-expressing alpha TC-1 cells with PC1/3-expressing alpha TCdeltaPC2 cells in normal mice and low-dose streptozotocin-treated mice | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
CD-1 mice and C57B/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | alphaTCdeltaPC2 cells express abundant PC1/3, whereas alphaTC-1 cells express little or no PC1/3 | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
proglucagon + H2O | - |
Mus musculus | glucagon-like peptide 1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC1/3 | - |
Mus musculus |
prohormone convertase 1/3 | - |
Mus musculus |