Activating Compound | Comment | Organism | Structure |
---|---|---|---|
6-n-propyl-2-thiouracil | produces hypothyroidism and induces a significant increase in the expression of PC1/3 in the paraventricular nucleus and lateral hypothalamus, but not ventromedial nucleus. Regulates colocalization of PC1/3 or PC2 in pro-thyrotropin-releasing hormone in the paraventricular nucleus, but not in lateral hypothalamus and ventromedial nucleus | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
adult male Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | paraventricular nucleus, lateral hypothalamus and ventromedial nucleus | Rattus norvegicus | - |
hypothalamus | - |
Rattus norvegicus | - |
neuron | discrete expression of PC1/3 in the paraventricular nucleus, lateral hypothalamus and ventromedial nucleus of euthyroid animals | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothyrotropin-releasing hormone + H2O | - |
Rattus norvegicus | thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC1/3 | - |
Rattus norvegicus |
prohormone convertase | - |
Rattus norvegicus |