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Literature summary for 3.4.21.93 extracted from
- Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells (1998), Protein Expr. Purif., 14, 353-366.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinant enzyme expressed in Sf9 cells, mPC1 cDNA inserted intoAutographa californica nuclear polyhedrosis virus, infection of Sf9 cells, mPC1 insert excised from recombinant vaccinia virus vector containg full-length cDNA | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| tunicamycin | - |
Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | cleaves polypeptide hormones and many proteins at specific sites | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
mouse | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | N-glycosylated | Mus musculus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme | Mus musculus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 8000 | - |
- |
Mus musculus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, kept frozen in cell culture medium, activity is stable for months | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dynorphin-A 1-17 + H2O | - |
Mus musculus | ? | - |
? | |
| additional information | cleaves polypeptide hormones and many proteins at specific sites | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mPC1 | - |
Mus musculus |
| mPC3 | - |
Mus musculus |
| mSPC3 | - |
Mus musculus |
| murine proprotein convertase-1 | - |
Mus musculus |
| murine proprotein convertase-1/3 | - |
Mus musculus |
| PC1/PC3 | - |
Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Mus musculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 8.5 | - |
Mus musculus |
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