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Literature summary for 3.4.21.93 extracted from
- Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes (2003), Biochem. J., 373, 231-239.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| profurin 39-62 DYYHFWHRGVKRSLSPHRPRHSR | - |
Mus musculus |  |
| profurin 48-62 VTKRSLSPHRPRHSR | - |
Mus musculus | |
| profurin 54-62 SPHRPRHSR | - |
Mus musculus | |
| proPC1/3 39-62/A NAYLF KAKSAPRRSRRSALAITKR | - |
Mus musculus | |
| proPC1/3 39-62/A NHYLF KHKSHPRRSALAITKR | - |
Mus musculus | |
| proPC1/3 50-62/A RRSRR SALHITKR | - |
Mus musculus | |
| proPC1/3 50-83 RRSRRSALHITKRLSDDDRVTWAEQQYEKERSKR | - |
Mus musculus | |
| proPC1/3 55-62 SALHITKR | - |
Mus musculus | |
| proPC1/3 55-62/A SALAITKR | - |
Mus musculus | |
| proPC1/3 55-83 SALHITKRLSDDDRVTWAEQQYEKERSKR | - |
Mus musculus | |
| proPC1/3 74-83 QQYEKERSKR | - |
Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
mouse | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pGlu-Arg-Thr-Lys-Arg-4-methylcoumarin-7-amide + H2O | - |
Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PC1/3 | - |
Mus musculus |
| proprotein convertase 1/3 | - |
Mus musculus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0003 | - |
proPC1/3 55-83 SALHITKRLSDDDRVTWAEQQYEKERSKR | pH 7.0, 25°C | Mus musculus | |
| 0.0006 | - |
proPC1/3 55-83 SALHITKRLSDDDRVTWAEQQYEKERSKR | pH 7.0, 25°C | Mus musculus | |
| 0.0007 | - |
proPC1/3 64-83 SDDDRVTWAEQQYEKERSKR | pH 7.0, 25°C | Mus musculus | |
| 0.00089 | - |
proPC1/3 74-83 QQYEKERSKR | pH 7.0, 25°C, competitive inhibition | Mus musculus | |
| 0.0024 | - |
proPC1/3 55-83 SALHITKRLSDDDRVTWAEQQYEKERSKR | pH 7.0, 25°C, mixed inhibition | Mus musculus | |
| 0.0036 | - |
profurin 48-62 VTKRSLSPHRPRHSR | pH 7.0, 25°C | Mus musculus | |
| 0.0102 | - |
profurin 39-62 DYYHFWHRGVKRSLSPHRPRHSR | pH 7.0, 25°C | Mus musculus | |
| 0.011 | - |
proPC1/3 64-83 SDDDRVTWAEQQYEKERSKR | pH 7.0, 25°C,mixed inhibition | Mus musculus | |
| 0.0182 | - |
proPC1/3 50-62/A RRSRR SALHITKR | pH 7.0, 25°C | Mus musculus | |
| 0.0186 | - |
proPC1/3 55-62 SALHITKR | pH 7.0, 25°C | Mus musculus | |
| 0.0221 | - |
proPC1/3 55-62/A SALAITKR | pH 7.0, 25°C | Mus musculus | |
| 0.0432 | - |
proPC1/3 39-62/A NAYLF KAKSAPRRSRRSALAITKR | pH 7.0, 25°C | Mus musculus | |
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