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Literature summary for 3.4.21.93 extracted from

  • Steiner, D.F.; Smeekens, S.P.; Ohagi, S.; Chan, S.J.
    The new enzymology of precursor processing endoproteases (1992), J. Biol. Chem., 267, 23435-23438.
    View publication on PubMed
Search for more literature for 3.4.21.93

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Pro-opiomelanocortin + H2O Mus musculus the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors ?
-
 ?
Pro-opiomelanocortin + H2O Homo sapiens the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors ?
-
 ?
Proinsulin + H2O Mus musculus the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors ?
-
 ?
Proinsulin + H2O Homo sapiens the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AtT-20 cell anterior Mus musculus
-
pancreatic islet
-
 Mus musculus
-
pancreatic islet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Pro-opiomelanocortin + H2O
-
 Mus musculus Adrenocorticotropic hormone + beta-lipotropin + beta endorphin small amounts of beta-endorphin ?
Pro-opiomelanocortin + H2O
-
 Homo sapiens Adrenocorticotropic hormone + beta-lipotropin + beta endorphin small amounts of beta-endorphin ?
Pro-opiomelanocortin + H2O the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors Mus musculus ?
-
 ?
Pro-opiomelanocortin + H2O the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors Homo sapiens ?
-
 ?
Proinsulin + H2O cleaves at both C peptide junctions to release rat insulin I but generates a larger proportion of intermediate cleaved at the B chain-C peptide junction, indicating a preference for this site Mus musculus Insulin + ?
-
 ?
Proinsulin + H2O cleaves at both C peptide junctions to release rat insulin I but generates a larger proportion of intermediate cleaved at the B chain-C peptide junction, indicating a preference for this site Homo sapiens Insulin + ?
-
 ?
Proinsulin + H2O the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors Mus musculus ?
-
 ?
Proinsulin + H2O the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors Homo sapiens ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
-
 Mus musculus
5.5
-
-
 Homo sapiens