Crystallization (Comment) | Organism |
---|---|
the X-ray structure of PfClpP shows the protein as a compacted tetradecamer | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.065 | - |
Suc-LLVY-4-methylcoumarin-7-amide | 30°C, pH 7.0 | Plasmodium falciparum | |
0.065 | - |
Suc-LLVY-4-methylcoumarin-7-amide | succinyl-LLVY-7-amido-4-methylcoumarin | Plasmodium falciparum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
apicoplast | - |
Plasmodium falciparum | 20011 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
Western blot | Plasmodium falciparum |
43000 | - |
calculated from cDNA, unprocessed protein | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | O97252 | parasite contains four Clp ATPases, one protease subunit ClpP and one inactive protease ClpR | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O | - |
Plasmodium falciparum | ? | - |
? | |
Suc-AAPF-4-methylcoumarin-7-amide + H2O | - |
Plasmodium falciparum | ? | - |
? | |
Suc-AFK-4-methylcoumarin-7-amide + H2O | - |
Plasmodium falciparum | ? | - |
? | |
Suc-IA-4-methylcoumarin-7-amide + H2O | - |
Plasmodium falciparum | ? | - |
? | |
Suc-IIW-4-methylcoumarin-7-amide + H2O | - |
Plasmodium falciparum | ? | - |
? | |
Suc-LY-4-methylcoumarin-7-amide + H2O | - |
Plasmodium falciparum | ? | - |
? | |
succinyl-LLVY-7-amido-4-methylcoumarin + H2O | - |
Plasmodium falciparum | succinyl-LLVY + 7-amino-4-methylcoumarin | - |
? |
Subunits | Comment | Organism |
---|---|---|
heptamer | homoheptamer, gel filtration | Plasmodium falciparum |
tetradecamer | crystal structure | Plasmodium falciparum |
Synonyms | Comment | Organism |
---|---|---|
PfClpP | - |
Plasmodium falciparum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000036 | - |
succinyl-LLVY-7-amido-4-methylcoumarin | 30°C, pH 7.0, PfClpP is a very weak peptidase on its own | Plasmodium falciparum |