Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for the development of structure-based antiviral drugs against ZIKV and related pathogenic flaviviruses | Zika virus |
Crystallization (Comment) | Organism |
---|---|
purified free NS2B-NS3 protease and complexed with a peptide reversely oriented at the active site, X-ray diffraction structure determination and analysis at 1.58 A resolution. A second protease in the same crystal binds to the residues K14K15G16E17 from the neighboring NS3 in reverse orientation, resisting proteolysis | Zika virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Zika virus | - |
ZIKV | - |
Synonyms | Comment | Organism |
---|---|---|
NS2B-NS3 protease | - |
Zika virus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NS2B cofactor | - |
Zika virus |
General Information | Comment | Organism |
---|---|---|
additional information | the unlinked NS2B-NS3 protease adopts a closed conformation in which NS2B engages NS3 to form an empty substrate-binding site | Zika virus |
physiological function | viral NS2B-NS3 protease processes viral polyprotein and is essential for the virus replication | Zika virus |