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Literature summary for 3.4.21.91 extracted from

  • Zhang, Z.; Li, Y.; Loh, Y.R.; Phoo, W.W.; Hung, A.W.; Kang, C.; Luo, D.
    Crystal structure of unlinked NS2B-NS3 protease from Zika virus (2016), Science, 354, 1597-1600 .
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme is a target for the development of structure-based antiviral drugs against ZIKV and related pathogenic flaviviruses Zika virus

Crystallization (Commentary)

Crystallization (Comment) Organism
purified free NS2B-NS3 protease and complexed with a peptide reversely oriented at the active site, X-ray diffraction structure determination and analysis at 1.58 A resolution. A second protease in the same crystal binds to the residues K14K15G16E17 from the neighboring NS3 in reverse orientation, resisting proteolysis Zika virus

Organism

Organism UniProt Comment Textmining
Zika virus
-
ZIKV
-

Synonyms

Synonyms Comment Organism
NS2B-NS3 protease
-
Zika virus

Cofactor

Cofactor Comment Organism Structure
NS2B cofactor
-
Zika virus

General Information

General Information Comment Organism
additional information the unlinked NS2B-NS3 protease adopts a closed conformation in which NS2B engages NS3 to form an empty substrate-binding site Zika virus
physiological function viral NS2B-NS3 protease processes viral polyprotein and is essential for the virus replication Zika virus