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Literature summary for 3.4.21.91 extracted from

  • Hill, M.E.; Kumar, A.; Wells, J.A.; Hobman, T.C.; Julien, O.; Hardy, J.A.
    The unique cofactor region of zika virus NS2B-NS3 protease facilitates cleavage of key host proteins (2018), ACS Chem. Biol., 13, 2398-2405 .
    View publication on PubMed
Search for more literature for 3.4.21.91

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATG16L1 + H2O Zika virus human autophagy-related protein 16-1, high activity ?
-
 ?
eIF4G1 protein + H2O Zika virus human eukaryotic translation initiation factor 4 gamma 1, high activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Zika virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATG16L1 + H2O human autophagy-related protein 16-1, high activity Zika virus ?
-
 ?
ATG16L1 + H2O human autophagy-related protein 16-1 Zika virus ?
-
 ?
eIF4G1 protein + H2O human eukaryotic translation initiation factor 4 gamma 1, high activity Zika virus ?
-
 ?
eIF4G1 protein + H2O human eukaryotic translation initiation factor 4 gamma 1 Zika virus ?
-
 ?
additional information identification of 31 human proteins that are cleaved by the NS2B-NS3 protease. The cofactor NS2B is the principal determinant in ZVP substrate selection Zika virus ?
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 ?

Synonyms

Synonyms Comment Organism
NS2B-NS3 protease
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 Zika virus

Cofactor

Cofactor Comment Organism Structure
NS2B cofactor the unique cofactor region of zika virus NS2B-NS3 protease facilitates cleavage of key host proteins. The NS2B cofactor region from Zika virus protease is essential for recognition of host cell substrates. Replacing the NS2B region in another flavivirus protease enabled recognition of novel Zika-specific substrates by hybrid proteases, suggesting that the cofactor is the principal determinant in ZVP substrate selection Zika virus

General Information

General Information Comment Organism
additional information the unique cofactor region of zika virus NS2B-NS3 protease facilitates cleavage of key host proteins Zika virus
physiological function autophagy-related protein 16-1 (ATG16L1) and eukaryotic translation initiation factor 4 gamma 1 (eIF4G1) are dramatically depleted during Zika virus infection. ATG16L1 and eIF4G1 mediate type-II interferon production and host-cell translation, respectively, likely aiding immune system evasion and driving the Zika life cycle Zika virus