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Literature summary for 3.4.21.91 extracted from

  • Ang, M.J.; Li, Z.; Lim, H.A.; Ng, F.M.; Then, S.W.; Wee, J.L.; Joy, J.; Hill, J.; Chia, C.S.
    A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides (2014), Peptides, 52, 49-52.
    View publication on PubMed
Search for more literature for 3.4.21.91

Inhibitors

Inhibitors Comment Organism Structure
acetyl-Ala-Arg-agmatine
-
 Murray Valley encephalitis virus
acetyl-Ala-Arg-agmatine
-
 West Nile virus
acetyl-Ala-Lys-agmatine
-
 Murray Valley encephalitis virus
acetyl-Ala-Lys-agmatine
-
 West Nile virus
acetyl-Arg-Lys-agmatine
-
 Murray Valley encephalitis virus
acetyl-Arg-Lys-agmatine
-
 West Nile virus
acetyl-Lys-Lys-agmatine
-
 Murray Valley encephalitis virus
acetyl-Lys-Lys-agmatine
-
 West Nile virus
acetyl-Trp-Lys-agmatine
-
 Murray Valley encephalitis virus
acetyl-Trp-Lys-agmatine
-
 West Nile virus

Organism

Organism UniProt Comment Textmining
Murray Valley encephalitis virus
-
-
-
West Nile virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is highly specific toward lysines at the P2 and P3 positions West Nile virus ?
-
 ?
additional information enzyme is highly specific toward lysines at the P2 and P3 positions Murray Valley encephalitis virus ?
-
 ?
Pyr-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O
-
 Murray Valley encephalitis virus Pyr-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
-
 ?
pyroglutamic acid-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O
-
 West Nile virus pyroglutamic acid-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0168
-
 pH 8.0, 25°C Murray Valley encephalitis virus acetyl-Lys-Lys-agmatine
0.0187
-
 pH 8.0, 25°C West Nile virus acetyl-Lys-Lys-agmatine
0.0237
-
 pH 8.0, 25°C Murray Valley encephalitis virus acetyl-Arg-Lys-agmatine
0.0268
-
 pH 8.0, 25°C Murray Valley encephalitis virus acetyl-Trp-Lys-agmatine
0.0271
-
 pH 8.0, 25°C West Nile virus acetyl-Arg-Lys-agmatine
0.0305
-
 pH 8.0, 25°C West Nile virus acetyl-Trp-Lys-agmatine
0.0312
-
 pH 8.0, 25°C Murray Valley encephalitis virus acetyl-Ala-Lys-agmatine
0.0382
-
 pH 8.0, 25°C West Nile virus acetyl-Ala-Lys-agmatine
0.0471
-
 pH 8.0, 25°C Murray Valley encephalitis virus acetyl-Ala-Arg-agmatine
0.0532
-
 pH 8.0, 25°C West Nile virus acetyl-Ala-Arg-agmatine