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Literature summary for 3.4.21.91 extracted from

  • Wu, H.; Bock, S.; Snitko, M.; Berger, T.; Weidner, T.; Holloway, S.; Kanitz, M.; Diederich, W.E.; Steuber, H.; Walter, C.; Hofmann, D.; Weissbrich, B.; Spannaus, R.; Acosta, E.G.; Bartenschlager, R.; Engels, B.; Schirmeister, T.; Bodem, J.
    Novel dengue virus NS2B/NS3 protease inhibitors (2015), Antimicrob. Agents Chemother., 59, 1100-1109.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.91

Inhibitors

Inhibitors Comment Organism Structure
N-(6-nitro-2,3-dihydro-1,3-benzothiazol-2-yl)-2-([4-(trifluoromethyl)phenyl]sulfanyl)benzamide EC50 value 0.1 microM Dengue virus
N-(6-nitro-2,3-dihydro-1,3-benzothiazol-2-yl)-3-[(4-nitrophenyl)sulfanyl]benzamide EC50 value 0.3 microM Dengue virus

Organism

Organism UniProt Comment Textmining
Dengue virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Gly-Arg-Arg-7-amido-4-methylcoumarin + H2O substrate of isoform DENV-2 Dengue virus benzyloxycarbonyl-Gly-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
PhAc-Lys-Arg-Arg-7-amido-4-methylcoumarin + H2O substrate of isoform DENV-3 Dengue virus PhAc-Lys-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.021
-
 protease of serotype DENV-3, pH not specified in the publication, temperature not specified in the publication Dengue virus N-(6-nitro-2,3-dihydro-1,3-benzothiazol-2-yl)-2-([4-(trifluoromethyl)phenyl]sulfanyl)benzamide
0.022
-
 protease of serotype DENV-2, pH not specified in the publication, temperature not specified in the publication Dengue virus N-(6-nitro-2,3-dihydro-1,3-benzothiazol-2-yl)-2-([4-(trifluoromethyl)phenyl]sulfanyl)benzamide
0.026
-
 protease of serotype DENV-2, pH not specified in the publication, temperature not specified in the publication Dengue virus N-(6-nitro-2,3-dihydro-1,3-benzothiazol-2-yl)-3-[(4-nitrophenyl)sulfanyl]benzamide