Literature summary for 3.4.21.91 extracted from

Phong, W.Y.; Moreland, N.J.; Lim, S.P.; Wen, D.; Paradkar, P.N.; Vasudevan, S.G.
Dengue protease activity: the structural integrity and interaction of NS2B with NS3 protease and its potential as a drug target (2011), Biosci. Rep., 31, 399-409.

Search for more literature for 3.4.21.91

Application

Application	Comment	Organism
medicine	to validate NS2B as a potential target in allosteric inhibitor development, a cNS2B specific human monoclonal antibody (3F10) is used. 3F10 disrupts the interaction between cNS2B and NS3 in vitro and reduces DENV viral replication in HEK293 cells	Dengue virus type 2

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK293 cells	Dengue virus type 2

General Stability

General Stability	Organism
various truncations and mutations in the cNS2B sequence show that conformational integrity of the entire 47 amino acids is critical for protease activity. DENV-2 NS3 protease can be pulled-down and is trans-activated by cNS2B cofactors from DENV-1, -3, -4, and West Nile Virus	Dengue virus type 2

Organism

Organism	UniProt	Comment	Textmining
Dengue virus type 2	-	-	-

Synonyms

Synonyms	Comment	Organism
NS3 proteinase	-	Dengue virus type 2

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Release 2023.1 (January 2023)