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Literature summary for 3.4.21.91 extracted from

  • Schueller, A.; Yin, Z.; Brian Chia, C.S.; Doan, D.N.; Kim, H.K.; Shang, L.; Loh, T.P.; Hill, J.; Vasudevan, S.G.
    Tripeptide inhibitors of dengue and West Nile virus NS2B-NS3 protease (2011), Antiviral Res., 92, 96-101.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-naphthoyl-Lys-Arg-Arg
-
Dengue virus
2-naphthoyl-Lys-Arg-Arg
-
West Nile virus
4-aminobenzoyl-Lys-Arg-Arg
-
Dengue virus
4-aminobenzoyl-Lys-Arg-Arg
-
West Nile virus
4-aminobenzoyl-Lys-Lys-Arg
-
Dengue virus
4-aminobenzoyl-Lys-Lys-Arg
-
West Nile virus
4-aminophenylacetyl-Lys-Arg-Arg
-
Dengue virus
4-aminophenylacetyl-Lys-Arg-Arg
-
West Nile virus
4-phenylphenylacetyl-Lys-Arg-Arg
-
Dengue virus
4-phenylphenylacetyl-Lys-Arg-Arg
-
West Nile virus
4-phenylphenylacetyl-Lys-Lys-Arg
-
Dengue virus
4-phenylphenylacetyl-Lys-Lys-Arg
-
West Nile virus
acetyl-Lys-Arg-Arg
-
Dengue virus
acetyl-Lys-Arg-Arg
-
West Nile virus
acetyl-Lys-Lys-Arg
-
Dengue virus
acetyl-Lys-Lys-Arg
-
West Nile virus
benzoyl-Lys-Lys(acetyl)-Arg
-
Dengue virus
benzoyl-Lys-Lys(acetyl)-Arg
-
West Nile virus
benzoyl-Lys-Lys(benzoyl)-Arg
-
Dengue virus
benzoyl-Lys-Lys(benzoyl)-Arg
-
West Nile virus
benzoyl-Lys-Lys(benzyl)-Arg
-
Dengue virus
benzoyl-Lys-Lys(benzyl)-Arg
-
West Nile virus
benzoyl-Lys-Lys(p-anisoyl)-Arg
-
Dengue virus
benzoyl-Lys-Lys(p-anisoyl)-Arg
-
West Nile virus
benzoyl-Lys-Lys-Arg
-
Dengue virus
benzoyl-Lys-Lys-Arg
-
West Nile virus
benzoyl-Nle-Lys-Arg-Arg
-
Dengue virus
benzoyl-Nle-Lys-Arg-Arg
-
West Nile virus
cinnamoyl-Lys-Arg-Arg
-
Dengue virus
cinnamoyl-Lys-Arg-Arg
-
West Nile virus
cyclopropionyl-Lys-Lys-Arg
-
Dengue virus
cyclopropionyl-Lys-Lys-Arg
-
West Nile virus
phenylacetyl-Lys-Arg-Arg
-
Dengue virus
phenylacetyl-Lys-Arg-Arg
-
West Nile virus
phenylacetyl-Lys-Lys-Arg
-
Dengue virus
phenylacetyl-Lys-Lys-Arg
-
West Nile virus
phenylpropionyl-Lys-Arg-Arg
-
Dengue virus
phenylpropionyl-Lys-Arg-Arg
-
West Nile virus
propionyl-Lys-Arg-Arg
-
Dengue virus
propionyl-Lys-Arg-Arg
-
West Nile virus
propionyl-Lys-Lys-Arg
-
Dengue virus
propionyl-Lys-Lys-Arg
-
West Nile virus
trifluoroacetyl-Lys-Lys-Arg
-
Dengue virus
trifluoroacetyl-Lys-Lys-Arg
-
West Nile virus

Organism

Organism UniProt Comment Textmining
Dengue virus
-
-
-
West Nile virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-Nle-Lys-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
Dengue virus benzoyl-Nle-Lys-Arg-Arg + 7-amino-4-methylcoumarin
-
?
benzoyl-Nle-Lys-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
West Nile virus benzoyl-Nle-Lys-Arg-Arg + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
NS3 proteinase
-
Dengue virus
NS3 proteinase
-
West Nile virus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
assay at Dengue virus
20
-
assay at West Nile virus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
assay at Dengue virus
8.5
-
assay at West Nile virus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000056
-
pH 8.5, 20°C West Nile virus 4-phenylphenylacetyl-Lys-Lys-Arg
0.00038
-
pH 8.5, 20°C West Nile virus cyclopropionyl-Lys-Lys-Arg
0.00039
-
pH 8.5, 20°C West Nile virus phenylacetyl-Lys-Arg-Arg
0.00042
-
pH 8.5, 20°C West Nile virus benzoyl-Lys-Lys-Arg
0.0007
-
pH 8.5, 20°C West Nile virus phenylacetyl-Lys-Lys-Arg
0.00085
-
pH 8.5, 20°C West Nile virus propionyl-Lys-Lys-Arg
0.00097
-
pH 8.5, 20°C West Nile virus acetyl-Lys-Lys-Arg
0.00099
-
pH 8.5, 20°C West Nile virus 4-phenylphenylacetyl-Lys-Arg-Arg
0.0014
-
pH 8.5, 20°C West Nile virus cinnamoyl-Lys-Arg-Arg
0.0018
-
pH 8.5, 20°C West Nile virus 2-naphthoyl-Lys-Arg-Arg
0.0018
-
pH 8.5, 20°C West Nile virus trifluoroacetyl-Lys-Lys-Arg
0.0019
-
pH 8.5, 20°C West Nile virus 4-aminophenylacetyl-Lys-Arg-Arg
0.0024
-
pH 8.5, 20°C West Nile virus acetyl-Lys-Arg-Arg
0.0026
-
pH 8.5, 20°C West Nile virus benzoyl-Nle-Lys-Arg-Arg
0.0067
-
pH 8.5, 20°C Dengue virus phenylacetyl-Lys-Arg-Arg
0.0083
-
pH 8.5, 20°C West Nile virus benzoyl-Lys-Lys(p-anisoyl)-Arg
0.0085
-
pH 8.5, 20°C West Nile virus propionyl-Lys-Arg-Arg
0.0095
-
pH 8.5, 20°C Dengue virus benzoyl-Nle-Lys-Arg-Arg
0.0112
-
pH 8.5, 20°C Dengue virus 4-aminophenylacetyl-Lys-Arg-Arg
0.0122
-
pH 8.5, 20°C Dengue virus 4-phenylphenylacetyl-Lys-Lys-Arg
0.0158
-
pH 8.5, 20°C Dengue virus cinnamoyl-Lys-Arg-Arg
0.0197
-
pH 8.5, 20°C West Nile virus phenylpropionyl-Lys-Arg-Arg
0.0224
-
pH 8.5, 20°C West Nile virus 4-aminobenzoyl-Lys-Arg-Arg
0.0234
-
pH 8.5, 20°C Dengue virus 4-phenylphenylacetyl-Lys-Arg-Arg
0.0242
-
pH 8.5, 20°C West Nile virus benzoyl-Lys-Lys(benzyl)-Arg
0.0267
-
pH 8.5, 20°C Dengue virus 2-naphthoyl-Lys-Arg-Arg
0.033
-
pH 8.5, 20°C West Nile virus benzoyl-Lys-Lys(benzoyl)-Arg
0.0335
-
pH 8.5, 20°C West Nile virus 4-aminobenzoyl-Lys-Lys-Arg
0.058
-
pH 8.5, 20°C Dengue virus acetyl-Lys-Arg-Arg
0.112
-
pH 8.5, 20°C West Nile virus benzoyl-Lys-Lys(acetyl)-Arg
0.115
-
pH 8.5, 20°C Dengue virus acetyl-Lys-Lys-Arg
0.127
-
pH 8.5, 20°C Dengue virus benzoyl-Lys-Lys-Arg
0.167
-
pH 8.5, 20°C Dengue virus phenylacetyl-Lys-Lys-Arg
0.172
-
pH 8.5, 20°C Dengue virus cyclopropionyl-Lys-Lys-Arg
0.201
-
pH 8.5, 20°C Dengue virus 4-aminobenzoyl-Lys-Arg-Arg
0.218
-
pH 8.5, 20°C Dengue virus propionyl-Lys-Arg-Arg
0.274
-
pH 8.5, 20°C Dengue virus trifluoroacetyl-Lys-Lys-Arg
0.3
-
pH 8.5, 20°C, value above Dengue virus phenylpropionyl-Lys-Arg-Arg
0.3
-
pH 8.5, 20°C, value above Dengue virus 4-aminobenzoyl-Lys-Lys-Arg
0.3
-
pH 8.5, 20°C, value above Dengue virus propionyl-Lys-Lys-Arg
0.3
-
pH 8.5, 20°C, value above Dengue virus benzoyl-Lys-Lys(acetyl)-Arg
0.3
-
pH 8.5, 20°C, value above Dengue virus benzoyl-Lys-Lys(benzoyl)-Arg
0.3
-
pH 8.5, 20°C, value above Dengue virus benzoyl-Lys-Lys(p-anisoyl)-Arg
0.3
-
pH 8.5, 20°C, value above Dengue virus benzoyl-Lys-Lys(benzyl)-Arg