Literature summary for 3.4.21.91 extracted from

Kiat, T.S.; Pippen, R.; Yusof, R.; Ibrahim, H.; Khalid, N.; Rahman, N.A.
Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease (2006), Bioorg. Med. Chem. Lett., 16, 3337-3340.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Dengue virus type 2

Inhibitors

Inhibitors	Comment	Organism	Structure
4-hydroxypanduratin A	cyclohexenyl chalcone derivative, competetive inhibitor, compound from Boesenbergia rotunda (L.) Mansf. Kulturpfl.	Dengue virus type 2
alpinetin	compound from Boesenbergia rotunda (L.) Mansf. Kulturpfl.	Dengue virus type 2
cardamonin	chalcone, non-competetive inhibitor, compound from Boesenbergia rotunda (L.) Mansf. Kulturpfl.	Dengue virus type 2
panduratin A	cyclohexenyl chalcone derivative, competetive inhibitor, compound from Boesenbergia rotunda (L.) Mansf. Kulturpfl.	Dengue virus type 2
pinocembrin	compound from Boesenbergia rotunda (L.) Mansf. Kulturpfl.	Dengue virus type 2
pinostrobin	flavanone, non-competetive inhibitor, compound from Boesenbergia rotunda (L.) Mansf. Kulturpfl.	Dengue virus type 2

Organism

Organism	UniProt	Comment	Textmining
Dengue virus type 2	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Dengue virus type 2

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ac-Thr-Arg-Arg-7-amido-4-methylcoumarin + H2O	-	Dengue virus type 2	Ac-Thr-Arg-Arg + 7-amino-4-methylcoumarin	-	?
Boc-Gly-Arg-Arg-7-amido-4-methylcoumarin + H2O	-	Dengue virus type 2	Boc-Gly-Arg-Arg + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
NS2B/NS3 protease	-	Dengue virus type 2
NS3 protease	-	Dengue virus type 2

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.021	-	4-hydroxypanduratin A	-	Dengue virus type 2
0.025	-	panduratin A	-	Dengue virus type 2
0.345	-	pinostrobin	-	Dengue virus type 2
0.377	-	cardamonin	-	Dengue virus type 2

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Release 2023.1 (January 2023)