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Literature summary for 3.4.21.91 extracted from
- Yellow fever virus NS2B-NS3 protease: charged-to-alanine mutagenesis and deletion analysis define regions important for protease complex formation and function (2000), Virology, 275, 335-347.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| flavivirus polyprotein + H2O | Yellow fever virus | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Yellow fever virus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| flavivirus polyprotein + H2O | - |
Yellow fever virus | ? | - |
? | |
| additional information | cleavage preference for substrates containing basic amino acids | Yellow fever virus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| yellow fever virus NS2B-NS3-181 protease | - |
Yellow fever virus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NS2B protein | all cleavages of the flavivirus polyprotein mediated by the NS3 protease are believed to require cofactor activity of the NS2B protein | Yellow fever virus |
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Release 2023.1 (January 2023)
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