BRENDA - Enzyme Database
show all sequences of 3.4.21.90

Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures

Tong, L.; Wengler, G.; Rossmann, M.G.; J. Mol. Biol. 230, 228-247 (1993)

Data extracted from this reference:

Crystallization (Commentary)
Crystallization
Organism
-
Sindbis virus
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
autoinhibition by the presence of Trp264 side-chain in the S1 pocket after autocatalytic cleavage at Trp264
Sindbis virus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
togavirin has a similar tertiary structure to chymotrypsin
Sindbis virus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
Sindbis virus core protein + H2O
Sindbis virus
autocatalytic cleavage at Trp264, . Besides its catalytic activity it also plays important roles in the formation of the viral core, the recognition of the spike proteins during the budding process, the recognition and packaging of the viral RNA, and possibly the inhibition of the host cell protein synthesis
?
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Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Sindbis virus
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-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Sindbis virus core protein + H2O
autocatalytic cleavage at Trp264
29850
Sindbis virus
Hydrolyzed Sindbis core protein
-
29850
Sindbis virus
-
Sindbis virus core protein + H2O
autocatalytic cleavage at Trp264, . Besides its catalytic activity it also plays important roles in the formation of the viral core, the recognition of the spike proteins during the budding process, the recognition and packaging of the viral RNA, and possibly the inhibition of the host cell protein synthesis
29850
Sindbis virus
?
-
-
-
-
Crystallization (Commentary) (protein specific)
Crystallization
Organism
-
Sindbis virus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
autoinhibition by the presence of Trp264 side-chain in the S1 pocket after autocatalytic cleavage at Trp264
Sindbis virus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
togavirin has a similar tertiary structure to chymotrypsin
Sindbis virus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
Sindbis virus core protein + H2O
Sindbis virus
autocatalytic cleavage at Trp264, . Besides its catalytic activity it also plays important roles in the formation of the viral core, the recognition of the spike proteins during the budding process, the recognition and packaging of the viral RNA, and possibly the inhibition of the host cell protein synthesis
?
-
-
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Sindbis virus core protein + H2O
autocatalytic cleavage at Trp264
29850
Sindbis virus
Hydrolyzed Sindbis core protein
-
29850
Sindbis virus
-
Sindbis virus core protein + H2O
autocatalytic cleavage at Trp264, . Besides its catalytic activity it also plays important roles in the formation of the viral core, the recognition of the spike proteins during the budding process, the recognition and packaging of the viral RNA, and possibly the inhibition of the host cell protein synthesis
29850
Sindbis virus
?
-
-
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-
Other publictions for EC 3.4.21.90
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
695938
Wengler
The regulation of disassembly ...
Chikungunya virus, Ross River virus, Semliki forest virus, Sindbis virus
Arch. Virol.
154
381-390
2009
2
3
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3
3
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2
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1
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11
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2
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3
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3
3
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2
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1
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2
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699899
Warrier
Role of sindbis virus capsid p ...
Sindbis virus
J. Virol.
82
4461-4470
2008
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1
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35
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3
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1
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1
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1
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35
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1
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1
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29850
Tong
Refined structure of Sindbis v ...
Sindbis virus
J. Mol. Biol.
230
228-247
1993
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1
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1
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1
1
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2
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2
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1
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1
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1
1
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-
2
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29851
Kräusslich
Viral proteinases ...
Sindbis virus
Annu. Rev. Biochem.
57
701-754
1988
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1
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1
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1
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