Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of the biofilm mutant, DELTASSA_0351, that is deficient in type I signal peptidase (SPase). Although the growth curve of the DSSA_0351 mutant shows no significant difference from that of the wild-type strain SK36, biofilm assays using both microtitre plate assay and confocal laser scanning microscopy (CLSM) confirmed a sharp reduction in biofilm formation in the mutant compared to the wild-type strain and the paralogous mutant DSSA_0849. Evaluation of the functional impact of SPase on biofilm formation, transcriptome analysis compared to wild-type, overview. The growth rates of the wild-type, DSSA_0849 and DSSA_0351 strains are not significantly different. Proteomic analysis of mutant strain DELTASSA_0351, list of transcripts that are differentially regulated in DELTASSA_0351 | Streptococcus sanguinis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus sanguinis | A3CKV0 | - |
- |
Streptococcus sanguinis SK36 | A3CKV0 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
SPase | - |
Streptococcus sanguinis |
type I signal peptidase | - |
Streptococcus sanguinis |
General Information | Comment | Organism |
---|---|---|
malfunction | the biofilm mutant, DELTASSA_0351, is deficient in type I signal peptidase (SPase), phenotype, overview. Proteomic analysis of mutant strain DELTASSA_0351, list of transcripts that are differentially regulated in DELTASSA_0351 | Streptococcus sanguinis |
physiological function | involvement of signal peptidase I in Streptococcus sanguinis biofilm formation. Streptococcus sanguinis, a Gram-positive bacterium, is one of the most abundant species of the oral microbiota and it contributes to biofilm development in the oral cavity | Streptococcus sanguinis |